HMGB1 Review: Changes and significance of TNF-a, IL-6, IL-8, IL-10 and HMGB1 in serum and bronchoalveolar lavage fluid of children with lobar pneumonia

Pandemic pneumonia is a common childhood lower respiratory tract infection, is a common community-acquired pneumonia (community-acquired pneumonia, CAP) one. According to the World Health Organization (WHO), CAP is the first cause of the death of children under five years of age worldwide, accounting for 19% of the number of child deaths. In recent years, the incidence of lobular pneumonia was significantly higher, and the condition extended healing, to the clinical treatment difficulties. The pathogens are mainly caused by bacteria, viruses, mycoplasma, the main clinical manifestations of high fever, cough, and even breathing difficulties, and can lead to multi-system extra-pulmonary complications. Despite the emergence of new potent antibiotics, its morbidity and mortality have not decreased significantly. So far, the pathogenesis of childhood lobar pneumonia is not very clear, the immune mechanism has been the concern of the majority of scholars, and in this process, cytokines play an important role . (Tumor necrosis factor-a, TNF-a), interleukin-6 (IL-6), interleukin-6 (IL-6), interleukin-6 (IL-6) and interleukin-6 (IL-6) (IL-8), high mobility group protein B1 (HMGB1), etc., to promote inflammation, causing tissue damage; the other hand, the body by releasing anti-inflammatory factors, such as: white blood cells Interleukins-4 (IL-4), Interleukins-10 (IL-10), etc., inhibit inflammation and localize inflammation. If the pro-inflammatory and anti-inflammatory response balance, the lung environment is stable, once the loss of balance, the body appears compensatory anti-inflammatory response syndrome (Compensatory anti-inflammatory response syndrome, CARS) or systemic inflammatory response syndrome (Systemic inflammatory response Syndrome, SIRS). However, the role of cytokines in the pathogenesis of childhood lobar pneumonia is less reported, and its mechanism is not clear. Therefore, this study explores the changes of cytokines in the serum and bronchoalveolar lavage fluid (BALF) of children with large leaf pneumonia and the correlation between the changes of different cytokines in the progression of children with lobar pneumonia To evaluate the role of bronchial alveolar lavage in the treatment of childhood lobar pneumonia, to provide a theoretical basis for further understanding the mechanism of cytokines in the pathogenesis of childhood lobar pneumonia, and to provide a new laboratory for disease evaluation and evaluation of efficacy index.

Reference

Christ-Crain M, Opal SM. Clinical review: The role of biomarkers in the diagnosis and management of community-acquired pneumonia. Critical Care. 2010;14(1):203. doi:10.1186/cc8155.

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