HMGB1 Review: Expression of HMGB1 / RAGE protein in esophageal squamous cell carcinoma and its clinical significance

HMGB1 cancer related pathway

Objective To investigate the expression of HMGB1 / RAGE protein in esophageal squamous cell carcinoma and its effect on the prognosis of esophageal squamous cell carcinoma. Methods The expression of HMGB1 and RAGE protein in 80 cases of esophageal squamous cell carcinoma was detected by immunohistochemistry. The relationship between HMGB1 and RAGE expression and clinicopathological factors and the prognosis of esophageal squamous cell carcinoma were analyzed by immunohistochemistry. The Results The positive expression rates of HMGB1 and RAGE protein in esophageal squamous cell carcinoma and normal squamous epithelium were 47.5% vs 17.5% and 72.5% vs 42.5%, respectively. The positive expression of HMGB1 and RAGE protein was (P <0.05), and there was a positive correlation between the expression of HMGB1 and RAGE (P <0.05), and there was a positive correlation between the expression of HMGB1 and RAGE (r = -0.51, -0.242, P <0.05) (R = 0.35, P = 0.001). HMGB1 and RAGE were positive for esophageal squamous cell carcinoma. COX analysis showed that HMGB1 was an independent factor in the prognosis of esophageal squamous cell carcinoma (HR = 4.853, P = 0.000). Conclusion The expression of HMGB1 and RAGE protein is closely related to the clinicopathological features of esophageal squamous cell carcinoma. The binding of HMGB1 to its receptor RAGE may be involved in the invasion and metastasis of esophageal squamous cell carcinoma. HMGB1 can be used as an important prognostic indicator of esophageal squamous cell carcinoma.

Reference

Zhao C-B, Bao J-M, Lu Y-J, et al. Co-expression of RAGE and HMGB1 is associated with cancer progression and poor patient outcome of prostate cancer. American Journal of Cancer Research. 2014;4(4):369-377.

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