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High mobility group protein B1 (HMGB1) is an important late-stage medium of sepsis caused by severe infection and participates in the process of multiple organ damage, including lung, liver and intestine. The use of HMGB1 neutralizing antibodies or specific antagonists to inhibit its secretion (pyruvate, alpha7 nicotinic acetylcholine receptor agonists) or down-regulation of its gene expression (n-butyrate, signaling pathway inhibitor) Reduce the effect of tissue damage, and may open up new ways for the prevention and treatment of severe sepsis.
Palumbo R, Sampaolesi M, De Marchis F, et al. Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. The Journal of Cell Biology. 2004;164(3):441-449. doi:10.1083/jcb.200304135.