Anti-AARS2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AARS2 Antibody (CSB-PA711453ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Alanyl-tRNA synthetase Antibody, AlaRS Antibody,AARS2 Antibody,AARSL Antibody, KIAA1270 Antibody

More alternative names for the antibody
AARS 2 antibody|AARS2 antibody|AARSL antibody|Alanine tRNA ligase 2 mitochondrial antibody|Alanine tRNA ligase antibody|Alanyl tRNA synthetase 2 mitochondrial antibody|Alanyl tRNA synthetase like antibody|AlaRS antibody|bA444E17.1 antibody|COXPD8 antibody|Gm89 antibody|KIAA1270 antibody|LKENP antibody|MGC69820 antibody|MT ALARS antibody|MTALARS antibody|Probable alanyl tRNA synthetase mitochondrial antibody|RP11-444E17.1 antibody
Anti-Alanyl-tRNA synthetase 2 antibody (ab197367)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AARS2 Antibody

Catalogue No.

CSB-PA711453ESR2HU

Reactivity

Human

Immunogen

Recombinant human Alanine–tRNA ligase, mitochondrial protein (841-985AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

107 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:57505( Human), Entrez Gene:224805( Mouse), Entrez Gene:301254( Rat), Omim:612035( Human), SwissProt:Q5JTZ9( Human), SwissProt:Q14CH7( Mouse)

Protein function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. .

Involvement in disease

Combined oxidative phosphorylation deficiency 8 (COXPD8) [MIM:614096]: A mitochondrial disease characterized by a lethal infantile hypertrophic cardiomyopathy, generalized muscle dysfunction and some neurologic involvement. The liver is not affected. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Leukoencephalopathy, progressive, with ovarian failure (LKENP) [MIM:615889]: An autosomal recessive neurodegenerative disorder characterized by childhood- to adulthood-onset of signs of neurologic deterioration consisting of ataxia, spasticity, and cognitive decline with features of frontal lobe dysfunction. Brain MRI shows leukoencephalopathy with striking involvement of deep white matter, and cerebellar atrophy. All female patients develop premature ovarian failure. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the class-II aminoacyl-tRNA synthetase family. Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.

Protein cellular localization

Mitochondrion .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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