Anti-ACTL6A Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC,ChIP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ACTL6A Antibody (CSB-PA001236ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

53 kDa BRG1-associated factor A Antibody,Actin-related protein Baf53a Antibody,ArpNbeta Antibody,BRG1-associated factor 53A Antibody,BAF53A Antibody,INO80 complex subunit K Antibody,ACTL6A Antibody,BAF53 Antibody, BAF53A Antibody, INO80K Antibody

More alternative names for the antibody
53 kDa BRG1 associated factor A antibody|Actin-like protein 6A antibody|ACTL 6 antibody|ACTL 6A antibody|ACTL6 antibody|ACTL6A antibody|Arp4 antibody|ARPN BETA antibody|ArpNbeta antibody|BAF 53A antibody|BAF complex 53 kDa subunit antibody|BAF53 antibody|BAF53A antibody|BRG1 associated factor antibody|BRG1-associated factor 53A antibody|hArpN beta antibody|INO80 complex subunit K antibody|INO80K antibody|MGC5382 antibody
Anti-BAF53A antibody – ChIP Grade (ab3882)
Close sc-137063|sc-271011|sc-271226|sc-271177|sc-137062|sc-137081|sc-47808|

Recommended applications: ELISA, WB, IHC, ChIP

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ACTL6A Antibody

Catalogue No.

CSB-PA001236ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Actin-like protein 6A protein (1-280AA)

Host

Rabbit

Applications

ELISA, WB, IHC, ChIP

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

47 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:86( Human), Entrez Gene:56456( Mouse), Entrez Gene:361925( Rat), Omim:604958( Human), SwissProt:O96019( Human), SwissProt:Q9Z2N8( Mouse), Unigene:435326( Human), Unigene:41077( Mouse), Unigene:31666( Rat)

Protein function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. .

Protein sequence and domain

Belongs to the actin family.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>BAF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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