Anti-ACTL6B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ACTL6B Antibody (CSB-PA001237ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

53 kDa BRG1-associated factor B Antibody,Actin-related protein Baf53b Antibody,ArpNalpha Antibody,BRG1-associated factor 53B Antibody, BAF53B Antibody,ACTL6B Antibody,ACTL6 Antibody, BAF53B Antibody

More alternative names for the antibody
53 kDa BRG1 associated factor B antibody|Actl 6 antibody|ACTL 6B antibody|Actl6 antibody|ACTL6 B antibody|Actl6b antibody|Arp Na antibody|ArpN a antibody|ArpN alpha antibody|ArpNa antibody|ArpNalpha antibody|Baf 53b antibody|BAF53B antibody|BRG1-associated factor 53B antibody
Anti-BAF53b antibody [EPR10100(B)] (ab140642)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ACTL6B Antibody

Catalogue No.

CSB-PA001237ESR1HU

Reactivity

Human

Immunogen

Recombinant human Actin-like protein 6B protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

46 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:51412( Human), Entrez Gene:83766( Mouse), Entrez Gene:288563( Rat), Omim:612458( Human), SwissProt:O94805( Human), SwissProt:Q99MR0( Mouse), SwissProt:P86173( Rat), Unigene:259831( Human), Unigene:31646( Mouse), Unigene:44972( Rat)

Protein function

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). .

Protein sequence and domain

Belongs to the actin family.

Protein cellular localization

Nucleus.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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