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Rabbit Anti-ACVR2B Antibody (CSB-PA623829ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Activin receptor type IIB Antibody,ACTR-IIB Antibody,ACVR2B AntibodyMore alternative names for the antibody
Activin A receptor type IIB antibody|Activin receptor type 2B antibody|Activin receptor type IIB antibody|Activin receptor type-2B antibody|ActR IIB antibody|ACTR-IIB antibody|ActRIIB antibody|ACVR 2B antibody|ACVR2B antibody|AVR2B_HUMAN antibody|HTX4 antibody|MGC116908 antibody
Anti-Activin Receptor Type IIB antibody (ab76940)
Anti-Activin Receptor Type IIB antibody (ab76940)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Activin receptor type-2B protein (19-140AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:374213( Chicken), Entrez Gene:282131( Cow), Entrez Gene:93( Human), Entrez Gene:11481( Mouse), Entrez Gene:448845( Pig), Entrez Gene:25366( Rat), Omim:602730( Human), SwissProt:Q90670( Chicken), SwissProt:Q95126( Cow), SwissProt:Q13705( Human), SwissProt:P27040( Mouse), SwissProt:Q66T47( Pig), SwissProt:P38445( Rat), Unigene:174273( Human), Unigene:390239( Mouse), Unigene:24240( Rat)
|Protein function|| |
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. .
|Involvement in disease|| |
Heterotaxy, visceral, 4, autosomal (HTX4) [MIM:613751]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
|Protein post-translational modifications|| |
Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity. .
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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