Anti-ADAM9 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ADAM9 Antibody (CSB-PA618774ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ADAM 9 Antibody,Cellular disintegrin-related protein Antibody,Meltrin-gamma Antibody,Metalloprotease/disintegrin/cysteine-rich protein 9 Antibody,Myeloma cell metalloproteinase Antibody,ADAM9 Antibody,KIAA0021 Antibody, MCMP Antibody, MDC9 Antibody, MLTNG Antibody

More alternative names for the antibody
A disintegrin and metalloproteinase domain 9 antibody|Cone rod dystrophy 9 antibody|CORD9 antibody|Disintegrin and metalloproteinase domain 9 antibody|Disintegrin and metalloproteinase domain containing protein 9 antibody|KIAA0021 antibody|MCMP antibody|MDC 9 antibody|MDC9 antibody|Meltrin gamma antibody|Metalloprotease disintegrin cysteine rich protein 9 antibody|Mltng antibody|Myeloma cell metalloproteinase antibody
Anti-ADAM9 antibody (ab186833)
Close sc-135822|sc-23290|sc-377233|sc-50332|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ADAM9 Antibody

Catalogue No.

CSB-PA618774ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Disintegrin and metalloproteinase domain-containing protein 9 protein (475-685AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

90 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:8754( Human), Entrez Gene:11502( Mouse), Entrez Gene:290834( Rat), Omim:602713( Human), SwissProt:Q13443( Human), SwissProt:Q61072( Mouse), Unigene:591852( Human)

Protein function

Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. .; Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). .

Protein tissue specificity

Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. .

Involvement in disease

Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. .; Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). .

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .

Research area

All research areas>Synthesis and Degradation>ADAM
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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