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Rabbit Anti-ADAM9 Antibody (CSB-PA618774ESR1HU)
Supplier: CUSABIO BIOTECH CO.
ADAM 9 Antibody,Cellular disintegrin-related protein Antibody,Meltrin-gamma Antibody,Metalloprotease/disintegrin/cysteine-rich protein 9 Antibody,Myeloma cell metalloproteinase Antibody,ADAM9 Antibody,KIAA0021 Antibody, MCMP Antibody, MDC9 Antibody, MLTNG AntibodyMore alternative names for the antibody
A disintegrin and metalloproteinase domain 9 antibody|Cone rod dystrophy 9 antibody|CORD9 antibody|Disintegrin and metalloproteinase domain 9 antibody|Disintegrin and metalloproteinase domain containing protein 9 antibody|KIAA0021 antibody|MCMP antibody|MDC 9 antibody|MDC9 antibody|Meltrin gamma antibody|Metalloprotease disintegrin cysteine rich protein 9 antibody|Mltng antibody|Myeloma cell metalloproteinase antibody
Anti-ADAM9 antibody (ab186833)
Anti-ADAM9 antibody (ab186833)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Disintegrin and metalloproteinase domain-containing protein 9 protein (475-685AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. .; Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). .
|Protein tissue specificity|| |
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. .
|Involvement in disease|| |
Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein post-translational modifications|| |
Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. .; Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). .
|Protein cellular localization|| |
Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .
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CUSABIO BIOTECH CO.
|Product type|| |
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