Anti-ADSL Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ADSL Antibody (CSB-PA001397ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ASL Antibody,Adenylosuccinase Antibody,ASase Antibody,ADSL Antibody,AMPS Antibody

More alternative names for the antibody
Adenylosuccinase antibody|Adenylosuccinate lyase antibody|ADSL antibody|AMPS antibody|ASase antibody|ASL antibody|OTTHUMP00000199172 antibody|OTTHUMP00000199173 antibody|PUR8_HUMAN antibody
Anti-Adenylosuccinate Lyase antibody [EPR10747(B)] (ab154182)
Close sc-365623|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ADSL Antibody

Catalogue No.

CSB-PA001397ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Adenylosuccinate lyase protein (1-310AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

54 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:158( Human), Entrez Gene:11564( Mouse), Entrez Gene:315150( Rat), Omim:608222( Human), SwissProt:P30566( Human), SwissProt:P54822( Mouse), Unigene:75527( Human), Unigene:38151( Mouse)

Protein function

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. .

Protein tissue specificity

Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.

Involvement in disease

Adenylosuccinase deficiency (ADSLD) [MIM:103050]: An autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Research area

All research areas>Synthesis and Degradation>ADSL
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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