Anti-AFAP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AFAP1 Antibody (CSB-PA839800ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

110 kDa actin filament-associated protein Antibody, AFAP-110 Antibody,AFAP1 Antibody,AFAP Antibody

More alternative names for the antibody
110 kDa actin filament associated protein antibody|110 kDa actin filament-associated protein antibody|Actin filament associated protein 1 antibody|Actin filament associated protein 110 kDa antibody|Actin filament-associated protein 1 antibody|AFAP 1 antibody|AFAP 110 antibody|AFAP antibody|AFAP-110 antibody|Afap1 antibody|AFAP1_HUMAN antibody|AFAP110 antibody|FLJ56849 antibody
Anti-AFAP antibody [2G9] (ab170553)
Close sc-374655|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AFAP1 Antibody

Catalogue No.

CSB-PA839800ESR2HU

Reactivity

Human

Immunogen

Recombinant human Actin filament-associated protein 1 protein (461-730AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

80 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:374034( Chicken), Entrez Gene:60312( Human), Entrez Gene:70292( Mouse), Entrez Gene:140935( Rat), Omim:608252( Human), SwissProt:Q90738( Chicken), SwissProt:Q8N556( Human), SwissProt:Q80YS6( Mouse), SwissProt:Q8VH46( Rat), Unigene:529369( Human), Unigene:125167( Mouse), Unigene:208751( Rat)

Protein function

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. .

Protein tissue specificity

Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. .

Protein post-translational modifications

Phosphorylated on tyrosine residues by SRC. .

Protein cellular localization

Cytoplasm, cytoskeleton . Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.

Research area

All research areas>Signaling Intermediates>AFAP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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