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Rabbit Anti-AKAP10 Antibody (CSB-PA001519ESR2HU)
Supplier: CUSABIO BIOTECH CO.
AKAP-10 Antibody,Dual specificity A kinase-anchoring protein 2 Antibody, D-AKAP-2 Antibody,Protein kinase A-anchoring protein 10 Antibody,PRKA10 Antibody,AKAP10 AntibodyMore alternative names for the antibody
1500031L16Rik antibody|A kinase (PRKA) anchor protein 10 antibody|A kinase anchor protein 10 antibody|A kinase anchor protein 10 mitochondrial antibody|A-kinase anchor protein 10 antibody|AKA10_HUMAN antibody|akap 10 antibody|AKAP-10 antibody|AKAP10 antibody|B130049N18Rik antibody|D AKAP 2 antibody|D-AKAP-2 antibody|dakap 2 antibody|dakap2 antibody|Dual specific A kinase anchoring protein 2 antibody|Dual specificity A kinase-anchoring protein 2 antibody|mgc9410 antibody|MGC9414| antibody|Mitochondrial A kinase PPKA anchor protein 10 antibody|mitochondrial antibody|prka 10 antibody|PRKA10 antibody|Protein A kinase anchoring protein 10 antibody|Protein A kinase anchoring protein 10 mitochondrial precursor antibody|Protein kinase A anchoring protein 10 antibody|Protein kinase A-anchoring protein 10 antibody
Anti-AKAP10 antibody (ab97354)
Anti-AKAP10 antibody (ab97354)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human A-kinase anchor protein 10, mitochondrial protein (413-662AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). .
|Involvement in disease|| |
Sudden cardiac death (SCD) [MIM:115080]: Unexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
|Protein sequence and domain|| |
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
|Protein cellular localization|| |
Mitochondrion . Membrane . Cytoplasm . Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
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CUSABIO BIOTECH CO.
|Product type|| |
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