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Rabbit Anti-AKAP8L Antibody (CSB-PA892152ESR1HU)
Supplier: CUSABIO BIOTECH CO.
AKAP8-like protein Antibody,Helicase A-binding protein 95 Antibody, HAP95 Antibody,Homologous to AKAP95 protein Antibody, HA95 Antibody,Neighbor of A-kinase-anchoring protein 95 Antibody,Neighbor of AKAP95 Antibody,AKAP8L Antibody,NAKAP Antibody, NAKAP95 Antibody,HRIHFB2018 AntibodyMore alternative names for the antibody
A kinase (PRKA) anchor protein 8 like antibody|A kinase anchor protein 8 like antibody|AKAP 8L antibody|AKAP8 like protein antibody|DKFZp434L0650 antibody|HA95 antibody|HAP95 antibody|Helicase A binding protein 95 antibody|Homologous to AKAP95 protein antibody|NAKAP antibody|NAKAP95 antibody|Neighbor of A kinase anchoring protein 95 antibody|Neighbor of AKAP95 antibody
Anti-AKAP8L antibody (ab51342)
Anti-AKAP8L antibody (ab51342)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human A-kinase anchor protein 8-like protein (1-240AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at ‘Ser-10’ of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). .; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436). .
|Protein tissue specificity|| |
Ubiquitously expressed. Expressed in the brain cortex (at protein level). .
|Protein sequence and domain|| |
Belongs to the AKAP95 family.
|Protein post-translational modifications|| |
Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta. .
|Protein cellular localization|| |
Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). .
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CUSABIO BIOTECH CO.
|Product type|| |
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