Anti-AKAP8L Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AKAP8L Antibody (CSB-PA892152ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

AKAP8-like protein Antibody,Helicase A-binding protein 95 Antibody, HAP95 Antibody,Homologous to AKAP95 protein Antibody, HA95 Antibody,Neighbor of A-kinase-anchoring protein 95 Antibody,Neighbor of AKAP95 Antibody,AKAP8L Antibody,NAKAP Antibody, NAKAP95 Antibody,HRIHFB2018 Antibody

More alternative names for the antibody
A kinase (PRKA) anchor protein 8 like antibody|A kinase anchor protein 8 like antibody|AKAP 8L antibody|AKAP8 like protein antibody|DKFZp434L0650 antibody|HA95 antibody|HAP95 antibody|Helicase A binding protein 95 antibody|Homologous to AKAP95 protein antibody|NAKAP antibody|NAKAP95 antibody|Neighbor of A kinase anchoring protein 95 antibody|Neighbor of AKAP95 antibody
Anti-AKAP8L antibody (ab51342)
Close sc-376630|sc-376338|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AKAP8L Antibody

Catalogue No.

CSB-PA892152ESR1HU

Reactivity

Human

Immunogen

Recombinant human A-kinase anchor protein 8-like protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

71 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:26993( Human), Entrez Gene:54194( Mouse), Entrez Gene:299569( Rat), Omim:609475( Human), SwissProt:Q9ULX6( Human), SwissProt:Q9R0L7( Mouse), Unigene:399800( Human)

Protein function

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at ‘Ser-10’ of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). .; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436). .

Protein tissue specificity

Ubiquitously expressed. Expressed in the brain cortex (at protein level). .

Protein sequence and domain

Belongs to the AKAP95 family.

Protein post-translational modifications

Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta. .

Protein cellular localization

Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). .

Research area

All research areas>Signaling Intermediates>AKAP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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