Anti-AKR1C4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AKR1C4 Antibody (CSB-PA001545ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

3-alpha-HSD1 Antibody,3-alpha-hydroxysteroid dehydrogenase type I Antibody,Chlordecone reductase Antibody,CDR Antibody,Dihydrodiol dehydrogenase 4 Antibody,DD-4 Antibody,DD4 Antibody,HAKRA Antibody,AKR1C4 Antibody,CHDR Antibody

More alternative names for the antibody
3 alpha HSD1 antibody|3-alpha-HSD1 antibody|3-alpha-hydroxysteroid dehydrogenase type I antibody|AK1C4_HUMAN antibody|AKR1C4 antibody|Aldo keto reductase family 1 member C4 antibody|Aldo-keto reductase family 1 member C4 antibody|CDR antibody|Chlordecone reductase antibody|DD-4 antibody|DD4 antibody|Dihydrodiol dehydrogenase 4 antibody|HAKRA antibody
Anti-HSD3a antibody (ab54606)
Close sc-100526|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AKR1C4 Antibody

Catalogue No.

CSB-PA001545ESR1HU

Reactivity

Human

Immunogen

Recombinant human Aldo-keto reductase family 1 member C4 protein (1-323AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

37 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1109( Human), Omim:600451( Human), SwissProt:P17516( Human), Unigene:567245( Human)

Protein function

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Protein tissue specificity

Liver specific. .

Involvement in disease

46,XY sex reversal 8 (SRXY8) [MIM:614279]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. . Note=The gene represented in this entry may act as a disease modifier. A splicing mutation resulting in loss of AKR1C4 exon 2 has been found in affected individuals carrying a causative mutation in AKR1C2 (PubMed:21802064). These patients manifest a more severe disease phenotype than individuals only carrying mutations in AKR1C2. .

Protein sequence and domain

Belongs to the aldo/keto reductase family.

Protein post-translational modifications

The N-terminus is blocked.

Protein cellular localization

Cytoplasm.

Research area

All research areas>Synthesis and Degradation>DD
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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