Anti-AKT1S1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AKT1S1 Antibody (CSB-PA836185DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Proline-rich AKT1 substrate 1 Antibody,40 kDa proline-rich AKT substrate Antibody,AKT1S1 Antibody

More alternative names for the antibody
40 kDa proline rich AKT substrate antibody|40 kDa proline-rich AKT substrate antibody|AKT1 S1 antibody|AKT1 substrate 1 (proline rich) antibody|AKT1 substrate 1 antibody|AKT1S 1 antibody|AKT1S1 antibody|AKTS1_HUMAN antibody|Lobe antibody|MGC2865 antibody|PRAS 40 antibody|PRAS antibody|PRAS40 antibody|Proline rich akt substrate antibody|Proline rich Akt substrate 40 kDa antibody|Proline-rich AKT1 substrate 1 antibody
Phospho anti-PRAS40 (T246) antibody (ab214100)
Close sc-32629|sc-377544|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AKT1S1 Antibody

Catalogue No.

CSB-PA836185DSR2HU

Reactivity

Human

Immunogen

Recombinant human Proline-rich AKT1 substrate 1 protein (132-256AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

27 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:84335( Human), Entrez Gene:67605( Mouse), Entrez Gene:292887( Rat), Omim:610221( Human), SwissProt:Q96B36( Human), SwissProt:Q9D1F4( Mouse), Unigene:515542( Human), Unigene:148007( Mouse)

Protein function

Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at ‘Thr-389’, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. .

Protein tissue specificity

Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293). .

Protein post-translational modifications

Phosphorylated by AKT1 (PubMed:12524439). Phosphorylation at Thr-246 by DYRK3 relieves inhibitory function on mTORC1 (PubMed:23415227). .

Protein cellular localization

Cytoplasm, cytosol . Note=Found in the cytosolic fraction of the brain. .

Research area

All research areas>Tumor Suppressor/Apoptosis>PRAS40
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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