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Rabbit Anti-ALKBH1 Antibody (CSB-PA614439ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Alpha-ketoglutarate-dependent dioxygenase ABH1 Antibody,DNA lyase ABH1 Antibody,DNA oxidative demethylase ALKBH1 Antibody,ALKBH1 Antibody,ABH Antibody, ABH1 Antibody, ALKBH AntibodyMore alternative names for the antibody
ABH antibody|ABH1 antibody|alkB antibody|alkB homolog 1 histone H2A dioxygenase antibody|AlkB, alkylation repair homolog 1 (E. coli) antibody|ALKB1_HUMAN antibody|ALKBH antibody|ALKBH1 antibody|Alkylated DNA repair protein alkB homolog 1 antibody|Alkylation repair homolog 1 antibody|Alkylation repair, alkB homolog antibody|Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody|DNA lyase ABH1 antibody|DNA oxidative demethylase ALKBH1 antibody|hABH antibody
Anti-ALKBH1 antibody [EPR6176] (ab126596)
Anti-ALKBH1 antibody [EPR6176] (ab126596)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Alkylated DNA repair protein alkB homolog 1 protein (110-389AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5′ DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity). .
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the alkB family.
|Protein cellular localization|| |
Nucleus . Mitochondrion . Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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