Anti-ALOXE3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ALOXE3 Antibody (CSB-PA863156ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Epidermis-type lipoxygenase 3 Antibody,Epidermal LOX-3 Antibody,e-LOX-3 Antibody,eLOX-3 Antibody,Hydroperoxy icosatetraenoate dehydratase Antibody,ALOXE3 Antibody

More alternative names for the antibody
ALOXE3 antibody|Arachidonate lipoxygenase 3 antibody|e LOX 3 antibody|E LOX antibody|e-LOX-3 antibody|eLOX3 antibody|Epidermal lipoxygenase antibody|Epidermis-type lipoxygenase 3 antibody|Lipoxygenase 3 antibody|LOXE3_HUMAN antibody
Anti-ALOXE3 antibody (ab118470)
Close sc-133275|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ALOXE3 Antibody

Catalogue No.

CSB-PA863156ESR1HU

Reactivity

Human

Immunogen

Recombinant human Hydroperoxide isomerase ALOXE3 protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

80 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:59344( Human), Entrez Gene:23801( Mouse), Entrez Gene:287424( Rat), Omim:607206( Human), SwissProt:Q9BYJ1( Human), SwissProt:Q9WV07( Mouse), Unigene:232770( Human), Unigene:41989( Mouse), Unigene:8716( Rat)

Protein function

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia. .

Protein tissue specificity

Predominantly expressed in skin.

Involvement in disease

Ichthyosis, congenital, autosomal recessive 3 (ARCI3) [MIM:606545]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the lipoxygenase family.

Protein cellular localization

Cytoplasm .

Research area

All research areas>Synthesis and Degradation>ALOXE
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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