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Rabbit Anti-ALOXE3 Antibody (CSB-PA863156ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Epidermis-type lipoxygenase 3 Antibody,Epidermal LOX-3 Antibody,e-LOX-3 Antibody,eLOX-3 Antibody,Hydroperoxy icosatetraenoate dehydratase Antibody,ALOXE3 AntibodyMore alternative names for the antibody
ALOXE3 antibody|Arachidonate lipoxygenase 3 antibody|e LOX 3 antibody|E LOX antibody|e-LOX-3 antibody|eLOX3 antibody|Epidermal lipoxygenase antibody|Epidermis-type lipoxygenase 3 antibody|Lipoxygenase 3 antibody|LOXE3_HUMAN antibody
Anti-ALOXE3 antibody (ab118470)
Anti-ALOXE3 antibody (ab118470)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:59344( Human), Entrez Gene:23801( Mouse), Entrez Gene:287424( Rat), Omim:607206( Human), SwissProt:Q9BYJ1( Human), SwissProt:Q9WV07( Mouse), Unigene:232770( Human), Unigene:41989( Mouse), Unigene:8716( Rat)
|Protein function|| |
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia. .
|Protein tissue specificity|| |
Predominantly expressed in skin.
|Involvement in disease|| |
Ichthyosis, congenital, autosomal recessive 3 (ARCI3) [MIM:606545]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the lipoxygenase family.
|Protein cellular localization|| |
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CUSABIO BIOTECH CO.
|Product type|| |
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