Anti-ALPL Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ALPL Antibody (CSB-PA001631ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

AP-TNAP Antibody,TNSALP Antibody,Alkaline phosphatase liver/bone/kidney isozyme Antibody,ALPL Antibody

More alternative names for the antibody
AKP2 antibody|Alkaline phosphatase antibody|Alkaline phosphatase liver/bone/kidney isozyme antibody|Alpl antibody|AP-TNAP antibody|HOPS antibody|Liver/bone/kidney isozyme antibody|PHOA antibody|PPBT_HUMAN antibody|Tissue non specific alkaline phosphatase antibody|Tissue nonspecific ALP antibody|tissue-nonspecific isozyme antibody|TNAP antibody|TNSALP antibody
Anti-Alkaline Phosphatase, Tissue Non-Specific antibody [EPR4477] (ab108337)
Close sc-30203|sc-28904|sc-15065|sc-374301|sc-367208|sc-161335|sc-376520|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ALPL Antibody

Catalogue No.

CSB-PA001631ESR2HU

Reactivity

Human

Immunogen

Recombinant human Alkaline phosphatase, tissue-nonspecific isozyme protein (20-270AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

57 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:249( Human), Entrez Gene:11647( Mouse), Entrez Gene:25586( Rat), Omim:171760( Human), SwissProt:P05186( Human), SwissProt:P09242( Mouse), SwissProt:P08289( Rat), Unigene:75431( Human), Unigene:288186( Mouse), Unigene:82764( Rat)

Protein function

This isozyme may play a role in skeletal mineralization.

Involvement in disease

Hypophosphatasia (HOPS) [MIM:146300]: A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. The adult form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia). . Note=The disease is caused by mutations affecting the gene represented in this entry.; Hypophosphatasia childhood type (HOPSC) [MIM:241510]: A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Hypophosphatasia infantile type (HOPSI) [MIM:241500]: A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe ‘rachitic’ skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the alkaline phosphatase family.

Protein post-translational modifications

N-glycosylated. .

Protein cellular localization

Cell membrane ; Lipid-anchor, GPI-anchor .

Research area

All research areas>Kinases and Phosphatases>Alkaline Phosphatase
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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