Anti-ANLN Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ANLN Antibody (CSB-PA800281ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Actin-binding protein anillin Antibody,ANLN Antibody

More alternative names for the antibody
Actin binding protein scraps homolog Drosophila antibody|Actin binding protein anillin antibody|Actin-binding protein anillin antibody|Anillin actin binding protein antibody|anln antibody|ANLN_HUMAN antibody|DKFZp779A055 antibody|FSGS8 antibody|Scra antibody|Scraps antibody|Scraps homolog antibody
Anti-Anillin antibody [CL0303] (ab211872)
Close sc-365181|sc-271814|sc-514638|sc-67327|sc-54857|sc-54859|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ANLN Antibody

Catalogue No.

CSB-PA800281ESR1HU

Reactivity

Human

Immunogen

Recombinant human Actin-binding protein anillin protein (845-1124AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

124 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:54443( Human), Omim:616027( Human), SwissProt:Q9NQW6( Human), Unigene:62180( Human)

Protein function

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636). .

Protein tissue specificity

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. .

Involvement in disease

Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Phosphorylated during mitosis. .; Ubiquitinated, and this requires FZR1/CDH1. .

Protein cellular localization

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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