Anti-AP2A1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AP2A1 Antibody (CSB-PA001869ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

100 kDa coated vesicle protein A Antibody,Adaptor protein complex AP-2 subunit alpha-1 Antibody,Adaptor-related protein complex 2 subunit alpha-1 Antibody,Alpha-adaptin A Antibody,Alpha1-adaptin Antibody,Clathrin assembly protein complex 2 alpha-A large chain Antibody,Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit Antibody,AP2A1 Antibody,ADTAA Antibody,CLAPA1 Antibody

More alternative names for the antibody
100 kDa coated vesicle protein A antibody|ADTAA antibody|Alpha A adaptin antibody|Alpha adaptin A antibody|Alpha-adaptin A antibody|alpha1 adaptin antibody|Alpha1-adaptin antibody|AP 2 alpha antibody|AP 2 complex subunit alpha 1 antibody|AP-2 complex subunit alpha-1 antibody|AP2 complex subunit alpha 1 antibody|AP2-ALPHA antibody|Ap2a1 antibody|AP2A1_HUMAN antibody|CLAPA 1 antibody|CLAPA1 antibody|Clathrin adaptor complex AP2. alpha subunit antibody|Clathrin assembly protein complex 2 alpha A large chain antibody|Clathrin assembly protein complex 2 alpha-A large chain antibody|Clathrin associated / assembly / adaptor protein large alpha 1 antibody|clathrin associated assembly adaptor protein large alpha 1 antibody|clathrin associated/assembly/adaptor protein, large, alpha 1 antibody|Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody|Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
Anti-alpha Adaptin antibody [AP6] (ab2730)
Close sc-377376|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AP2A1 Antibody

Catalogue No.

CSB-PA001869ESR1HU

Reactivity

Human

Immunogen

Recombinant human AP-2 complex subunit alpha-1 protein (1-260AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

107 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:515216( Cow), Entrez Gene:784636( Cow), Entrez Gene:160( Human), Entrez Gene:161( Human), Entrez Gene:11771( Mouse), Entrez Gene:11772( Mouse), Entrez Gene:308578( Rat), Entrez Gene:81637( Rat), Omim:601026( Human), Omim:607242( Human), SwissProt:Q0VCK5( Cow), SwissProt:O94973( Human), SwissProt:O95782( Human), SwissProt:P17426( Mouse), SwissProt:P17427( Mouse), SwissProt:P18484( Rat), Unigene:19121( Human), Unigene:6877( Mouse), Unigene:34928( Rat)

Protein function

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). .

Protein tissue specificity

Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.

Protein sequence and domain

Belongs to the adaptor complexes large subunit family.

Protein cellular localization

Cell membrane . Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side . Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. .

Research area

All research areas>Transport and Trafficking>Adaptin
(View all antibody categories related to Transport and Trafficking)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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