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Rabbit Anti-AP2B1 Antibody (CSB-PA001871ESR1HU)
Supplier: CUSABIO BIOTECH CO.
AP105B Antibody,Adaptor protein complex AP-2 subunit beta Antibody,Adaptor-related protein complex 2 subunit beta Antibody,Beta-2-adaptin Antibody,Beta-adaptin Antibody,Clathrin assembly protein complex 2 beta large chain Antibody,Plasma membrane adaptor HA2/AP2 adaptin beta subunit Antibody,AP2B1 Antibody,ADTB2 Antibody, CLAPB1 AntibodyMore alternative names for the antibody
Adaptin, beta 2 (beta) antibody|ADTB1 antibody|ADTB2 antibody|AP 1 complex subunit beta 1 antibody|AP 2 complex subunit beta 1 antibody|AP1 Beta antibody|AP1B1 antibody|AP2 Beta antibody|AP2B1 antibody|Beta1 adaptin antibody|Beta2 adaptin antibody|CLAPB1 antibody|CLAPB2 antibody
Anti-AP1+2 beta antibody (ab21981)
Anti-AP1+2 beta antibody (ab21981)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human AP-2 complex subunit beta protein (738-937AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:162( Human), Entrez Gene:163( Human), Entrez Gene:11764( Mouse), Entrez Gene:71770( Mouse), Entrez Gene:140670( Rat), Entrez Gene:29663( Rat), Omim:600157( Human), Omim:601025( Human), SwissProt:P63010( Human), SwissProt:Q10567( Human), SwissProt:O35643( Mouse), SwissProt:Q5SVG4( Mouse), SwissProt:Q5SVG5( Mouse), SwissProt:Q8CC13( Mouse), SwissProt:Q9DBG3( Mouse), SwissProt:P52303( Rat), SwissProt:P62944( Rat), Unigene:368794( Human), Unigene:514819( Human), Unigene:274816( Mouse), Unigene:39053( Mouse), Unigene:37383( Rat), Unigene:56138( Rat)
|Protein function|| |
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. .
|Protein sequence and domain|| |
Belongs to the adaptor complexes large subunit family.
|Protein post-translational modifications|| |
Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs). .
|Protein cellular localization|| |
Cell membrane . Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side . Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
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CUSABIO BIOTECH CO.
|Product type|| |
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