Anti-AP2M1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-AP2M1 Antibody (CSB-PA850274ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

AP-2 mu chain Antibody,Adaptin-mu2 Antibody,Adaptor protein complex AP-2 subunit mu Antibody,Adaptor-related protein complex 2 subunit mu Antibody,Clathrin assembly protein complex 2 mu medium chain Antibody,Clathrin coat assembly protein AP50 Antibody,Clathrin coat-associated protein AP50 Antibody,HA2 50 kDa subunit Antibody,Plasma membrane adaptor AP-2 50 kDa protein Antibody,AP2M1 Antibody,CLAPM1 Antibody, KIAA0109 Antibody

More alternative names for the antibody
AP 2 mu 2 chain antibody|AP-2 complex subunit mu antibody|AP-2 mu chain antibody|Ap2m1 antibody|AP2M1_HUMAN antibody|AP50 antibody|CLAPM1 antibody|Clathrin adaptor complex AP2 mu subunit antibody|Clathrin assembly protein complex 2 medium chain antibody|Clathrin associated/assembly/adaptor protein medium 1 antibody|Clathrin coat adaptor protein AP50 antibody|Clathrin coat assembly protein AP50 antibody|Clathrin coat associated protein AP50 antibody|Clathrin coat-associated protein AP50 antibody|HA2 50 kDa subunit antibody|mu2 antibody|Plasma membrane adaptor AP-2 50 kDa protein antibody
Anti-AP2M1 antibody [EP2695Y] (ab75995)
Close sc-49150|sc-99026|sc-49151|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-AP2M1 Antibody

Catalogue No.

CSB-PA850274ESR1HU

Reactivity

Human

Immunogen

Recombinant human AP-2 complex subunit mu protein (136-435AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

49 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1173( Human), Entrez Gene:11773( Mouse), Entrez Gene:116563( Rat), Omim:601024( Human), SwissProt:Q96CW1( Human), SwissProt:P84091( Mouse), SwissProt:P84092( Rat), Unigene:518460( Human), Unigene:18946( Mouse), Unigene:3172( Rat)

Protein function

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at ‘Tyr-156’ in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). .

Protein sequence and domain

Belongs to the adaptor complexes medium subunit family.

Protein cellular localization

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. .

Research area

All research areas>Transport and Trafficking>Adaptin Related Adapter Protein
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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