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Rabbit Anti-AP3B1 Antibody (CSB-PA001874ESR1HU)
Supplier: CUSABIO BIOTECH CO.
AP-3 complex subunit beta-1 Antibody,Adaptor protein complex AP-3 subunit beta-1 Antibody,Adaptor-related protein complex 3 subunit beta-1 Antibody,Beta-3A-adaptin Antibody,Clathrin assembly protein complex 3 beta-1 large chain Antibody,AP3B1 Antibody,ADTB3A AntibodyMore alternative names for the antibody
Adaptor protein complex AP-3 subunit beta-1 antibody|Adaptor protein complex AP3 beta1 subunit antibody|ADTB3 antibody|ADTB3A antibody|AP-3 complex subunit beta-1 antibody|AP3 complex beta1 subunit antibody|AP3B1 antibody|AP3B1_HUMAN antibody|Beta-3A-adaptin antibody|Beta3A adaptin antibody|Clathrin assembly protein complex 3 beta 1 large chain antibody|Clathrin assembly protein complex 3 beta-1 large chain antibody|HPS antibody|PE antibody
Anti-HPS2 antibody – C-terminal (ab197155)
Anti-HPS2 antibody – C-terminal (ab197155)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human AP-3 complex subunit beta-1 protein (895-1094AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=767602" target="_blank">Entrez Gene:767602( Cow)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=403459" target="_blank">Entrez Gene:403459( Dog)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8546" target="_blank">Entrez Gene:8546( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11774" target="_blank">Entrez Gene:11774( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/603401" target="_blank">Omim:603401( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q32PG1" target="_blank">SwissProt:Q32PG1( Cow)</a>, <a href="http://www.uniprot.org/uniprot/Q7YRF1" target="_blank">SwissProt:Q7YRF1( Dog)</a>, <a href="http://www.uniprot.org/uniprot/O00203" target="_blank">SwissProt:O00203( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9Z1T1" target="_blank">SwissProt:Q9Z1T1( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=532091" target="_blank">Unigene:532091( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=21185" target="_blank">Unigene:21185( Mouse)</a>
|Protein function|| |
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
|Protein tissue specificity|| |
Ubiquitously expressed. .
|Involvement in disease|| |
Hermansky-Pudlak syndrome 2 (HPS2) [MIM:608233]: A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. HPS2 differs from the other forms of HPS in that it includes immunodeficiency in its phenotype and patients with HPS2 have an increased susceptibility to infections. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the adaptor complexes large subunit family.
|Protein post-translational modifications|| |
Phosphorylated on serine residues. .
|Protein cellular localization|| |
Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus . Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. .
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transport-and-Trafficking/">Transport and Trafficking</a>><a href="https://antibodyplus.com/product-tag/Adaptin-Related-Adapter-Protein/">Adaptin Related Adapter Protein</a><br><a href="https://antibodyplus.com/product-tag/Transport-and-Trafficking/"> (View all antibody categories related to Transport and Trafficking)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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