Anti-APLP1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-APLP1 Antibody (CSB-PA001911ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

APLP Antibody,APLP-1 Antibody,C30 Antibody,APLP1 Antibody

More alternative names for the antibody
AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1 antibody|AMYLOID PRECURSOR-LIKE PROTEIN antibody|Amyloid-like protein 1 precursor antibody|APLP 1 antibody|APLP antibody|APLP-1 antibody|Aplp1 antibody|APLP1_HUMAN antibody|C30 antibody
Anti-APLP1 antibody – N-terminal (ab191066)
Close sc-367468|sc-23818|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-APLP1 Antibody

Catalogue No.

CSB-PA001911ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Amyloid-like protein 1 protein (39-300AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

72 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:333( Human), Entrez Gene:11803( Mouse), Entrez Gene:502317( Rat), Omim:104775( Human), SwissProt:P51693( Human), SwissProt:Q03157( Mouse), Unigene:74565( Human), Unigene:2381( Mouse)

Protein function

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. .; The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. .

Protein tissue specificity

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). .

Protein sequence and domain

Belongs to the APP family. The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.

Protein post-translational modifications

Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity). .; N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. .

Protein cellular localization

Cell membrane; Single-pass type I membrane protein.; C30: Cytoplasm. Note=C-terminally processed in the Golgi complex.

Research area

All research areas>Neurobiology Antibodies>APLP
(View all antibody categories related to Neurobiology Antibodies)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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