Anti-ARIH2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-ARIH2 Antibody (CSB-PA002069ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase ARIH2 Antibody,ARI-2 Antibody,Protein ariadne-2 homolog Antibody,Triad1 protein Antibody,ARIH2 Antibody,ARI2 Antibody,TRIAD1 Antibody,HT005 Antibody

More alternative names for the antibody
HT005 antibody|all trans retinoic acid inducible RING finger antibody|Ari 2 antibody|Ari-2 antibody|ARI2 antibody|ARI2_HUMAN antibody|Ariadne 2 antibody|Ariadne 2 protein homolog antibody|ariadne homolog 2 (Drosophila) antibody|ariadne homolog 2 antibody|Ariadne RBR E3 ubiquitin protein ligase 2 antibody|ARIH 2 antibody|Arih2 antibody|E3 ubiquitin protein ligase ARIH2 antibody|E3 ubiquitin-protein ligase ARIH2 antibody|protein ariadne 2 homolog antibody|Protein ariadne-2 homolog antibody|Triad 1 antibody|TRIAD1 antibody|Triad1 protein antibody|UIP48 antibody
Anti-ARIH2 antibody – C-terminal (ab151325)
Close

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ARIH2 Antibody

Catalogue No.

CSB-PA002069ESR1HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase ARIH2 protein (194-493AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

57 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:416061( Chicken), Entrez Gene:505320( Cow), Entrez Gene:10425( Human), Entrez Gene:23807( Mouse), Entrez Gene:316005( Rat), Omim:605615( Human), SwissProt:O95376( Human), SwissProt:Q9Z1K6( Mouse), Unigene:633601( Human), Unigene:290447( Mouse), Unigene:9570( Rat)

Protein function

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates ‘Lys-6’, ‘Lys-48’-and ‘Lys-63’-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). .

Protein tissue specificity

Widely expressed with higher expression in granulocytes. .

Protein sequence and domain

Belongs to the RBR family. Ariadne subfamily. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.; The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site.

Protein post-translational modifications

Ubiquitinated. Ubiquitination promotes proteasomal degradation. .

Protein cellular localization

Nucleus . Cytoplasm .

Research area

All research areas>Signaling Intermediates>TRIAD
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!