Anti-ASIC3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ASIC3 Antibody (CSB-PA890688ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Acid-sensing ion channel 3 Antibody,ASIC3 Antibody,hASIC3 Antibody,Amiloride-sensitive cation channel 3 Antibody,Neuronal amiloride-sensitive cation channel 3 Antibody,Testis sodium channel 1 Antibody,hTNaC1 Antibody,ASIC3 Antibody,ACCN3 Antibody,SLNAC1 Antibody,TNAC1 Antibody

More alternative names for the antibody
ACCN 3 antibody|Accn3 antibody|ACCN3_HUMAN antibody|Acid sensing ion channel 3 antibody|Acid-sensing ion channel 3 antibody|Amiloride sensitive cation channel 3 antibody|Amiloride sensitive cation channel 3 testis antibody|Amiloride-sensitive cation channel 3 antibody|ASIC 3 antibody|ASIC3 antibody|DRASIC antibody|hASIC 3 antibody|hASIC3 antibody|hTNaC 1 antibody|hTNaC1 antibody|Modulatory subunit of ASIC 2a antibody|Modulatory subunit of ASIC2a antibody|Neuronal amiloride sensitive cation channel 3 antibody|Neuronal amiloride-sensitive cation channel 3 antibody|Proton gated cation channel subunit antibody|SLNAC 1 antibody|SLNAC1 antibody|Testis sodium channel 1 antibody|TNaC 1 antibody|TNaC1 antibody
Anti-ASIC3 antibody (ab49333)
Close sc-368068|sc-21845|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ASIC3 Antibody

Catalogue No.

CSB-PA890688ESR1HU

Reactivity

Human

Immunogen

Recombinant human Acid-sensing ion channel 3 protein (62-320AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

58 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9311( Human), Entrez Gene:171209( Mouse), Entrez Gene:286920( Rat), Omim:611741( Human), SwissProt:Q9UHC3( Human), SwissProt:Q6X1Y6( Mouse), SwissProt:O35240( Rat), Unigene:647113( Human), Unigene:299636( Mouse), Unigene:24225( Rat)

Protein function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. .

Protein tissue specificity

Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. .

Protein sequence and domain

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.

Protein post-translational modifications

Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity). .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cytoplasm . Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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