Anti-ATF7 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ATF7 Antibody (CSB-PA002279ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

cAMP-dependent transcription factor ATF-7 Antibody,Activating transcription factor 7 Antibody,Transcription factor ATF-A Antibody,ATF7 Antibody,ATFA Antibody

More alternative names for the antibody
1110012F10Rik antibody|9430065F09Rik antibody|Activating transcription factor 7 antibody|AI549878 antibody|ATF7 antibody|Atf7 protein antibody|ATF7_HUMAN antibody|ATFA antibody|C130020M04Rik antibody|cAMP-dependent transcription factor ATF-7 antibody|Cyclic AMP-dependent transcription factor ATF 7 antibody|Cyclic AMP-dependent transcription factor ATF-7 antibody|MGC31554 antibody|MGC57182 antibody|Transcription factor ATF A antibody|Transcription factor ATF-A antibody
Anti-ATF7 antibody [EPR13556] (ab183507)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ATF7 Antibody

Catalogue No.

CSB-PA002279ESR1HU

Reactivity

Human

Immunogen

Recombinant human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

52 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:11016( Human), Entrez Gene:223922( Mouse), Entrez Gene:315333( Rat), Omim:606371( Human), SwissProt:P17544( Human), SwissProt:Q8R0S1( Mouse), Unigene:12286( Human), Unigene:208714( Mouse), Unigene:475149( Mouse), Unigene:219706( Rat)

Protein function

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.; Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Protein tissue specificity

Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. .

Protein sequence and domain

Belongs to the bZIP family.

Protein post-translational modifications

On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity. .; Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.

Protein cellular localization

Nucleus . Nucleus, nucleoplasm . Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; Isoform 5: Cytoplasm .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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