Anti-ATG13 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ATG13 Antibody (CSB-PA012203ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ATG13 Antibody,KIAA0652 Antibody,Autophagy-related protein 13 Antibody

More alternative names for the antibody
ATG13 antibody|FLJ20698 antibody|KIAA0652 antibody|OTTHUMP00000233321 antibody|OTTHUMP00000233322 antibody|OTTHUMP00000233323 antibody|OTTHUMP00000233324 antibody|OTTHUMP00000233325 antibody|OTTHUMP00000233326 antibody
Anti-KIAA0652 antibody [EPR19601] (ab201467)
Close sc-240548|sc-240546|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ATG13 Antibody

Catalogue No.

CSB-PA012203ESR1HU

Reactivity

Human

Immunogen

Recombinant human Autophagy-related protein 13 protein (318-517AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

56 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9776( Human), Entrez Gene:51897( Mouse), Entrez Gene:362164( Rat), SwissProt:O75143( Human), SwissProt:Q91YI1( Mouse), Unigene:127403( Human), Unigene:28492( Mouse), Unigene:98797( Rat)

Protein function

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

Protein sequence and domain

Belongs to the ATG13 family. Metazoan subfamily. The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and MAP1LC3A.

Protein post-translational modifications

Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria. .

Protein cellular localization

Cytoplasm, cytosol . Preautophagosomal structure . Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .

Research area

All research areas>Synthesis and Degradation>Atg
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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