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Rabbit Anti-ATG14 Antibody (CSB-PA741052ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Barkor Antibody,Autophagy-related protein 14-like protein Antibody,Atg14L Antibody,ATG14 Antibody,KIAA0831 AntibodyMore alternative names for the antibody
4832427M01 antibody|BAKOR_HUMAN antibody|D14Ertd114e antibody|D14Ertd436e antibody|KIAA0831 antibody|mCG_6911 antibody
Anti-ATG14L antibody (ab139727)
Anti-ATG14L antibody (ab139727)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Beclin 1-associated autophagy-related key regulator protein (1-310AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:22863( Human), Entrez Gene:100504663( Mouse), Entrez Gene:305831( Rat), Omim:613515( Human), SwissProt:Q6ZNE5( Human), SwissProt:Q8CDJ3( Mouse), SwissProt:D4A4K3( Rat), Unigene:414809( Human), Unigene:287279( Mouse), Unigene:47301( Rat)
|Protein function|| |
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). .
|Protein sequence and domain|| |
Belongs to the ATG14 family. The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy.; The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called BATS.; The N-terminal cysteine repeats are required for proper localization to the endoplasmic reticulum.
|Protein cellular localization|| |
Cytoplasm . Endoplasmic reticulum membrane ; Peripheral membrane protein . Preautophagosomal structure membrane ; Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein . Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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