Anti-ATG16L1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ATG16L1 Antibody (CSB-PA734569ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

APG16-like 1 Antibody,ATG16L1 Antibody,APG16L Antibody,UNQ9393/PRO34307 Antibody

More alternative names for the antibody
A16L1_HUMAN antibody|FLJ00045 antibody|FLJ10035 antibody|FLJ10828 antibody|FLJ22677 antibody|IBD10 antibody|OTTHUMP00000164391 antibody|OTTHUMP00000164393 antibody|OTTHUMP00000165876 antibody|OTTHUMP00000165877 antibody|WD repeat domain 30 antibody|WDR30 antibody
Anti-ATG16L1 antibody (ab47946)
Close sc-70133|sc-70134|sc-393274|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ATG16L1 Antibody

Catalogue No.

CSB-PA734569ESR1HU

Reactivity

Human

Immunogen

Recombinant human Autophagy-related protein 16-1 protein (90-300AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

68 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:101830467( Hamster), Entrez Gene:55054( Human), Entrez Gene:77040( Mouse), Omim:610767( Human), SwissProt:Q676U5( Human), SwissProt:Q8C0J2( Mouse), Unigene:529322( Human), Unigene:272972( Mouse), Unigene:456099( Mouse)

Protein function

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). .

Involvement in disease

Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the WD repeat ATG16 family.

Protein post-translational modifications

Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli. .; Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex. .

Protein cellular localization

Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. .

Research area

All research areas>Synthesis and Degradation>Atg
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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