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Rabbit Anti-ATG16L1 Antibody (CSB-PA734569ESR1HU)
Supplier: CUSABIO BIOTECH CO.
APG16-like 1 Antibody,ATG16L1 Antibody,APG16L Antibody,UNQ9393/PRO34307 AntibodyMore alternative names for the antibody
A16L1_HUMAN antibody|FLJ00045 antibody|FLJ10035 antibody|FLJ10828 antibody|FLJ22677 antibody|IBD10 antibody|OTTHUMP00000164391 antibody|OTTHUMP00000164393 antibody|OTTHUMP00000165876 antibody|OTTHUMP00000165877 antibody|WD repeat domain 30 antibody|WDR30 antibody
Anti-ATG16L1 antibody (ab47946)
Anti-ATG16L1 antibody (ab47946)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Autophagy-related protein 16-1 protein (90-300AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:101830467( Hamster), Entrez Gene:55054( Human), Entrez Gene:77040( Mouse), Omim:610767( Human), SwissProt:Q676U5( Human), SwissProt:Q8C0J2( Mouse), Unigene:529322( Human), Unigene:272972( Mouse), Unigene:456099( Mouse)
|Protein function|| |
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). .
|Involvement in disease|| |
Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the WD repeat ATG16 family.
|Protein post-translational modifications|| |
Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli. .; Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex. .
|Protein cellular localization|| |
Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. .
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CUSABIO BIOTECH CO.
|Product type|| |
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