Anti-ATP7B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ATP7B Antibody (CSB-PA002415ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Copper pump 2 Antibody,Wilson disease-associated protein Antibody,ATP7B Antibody,PWD Antibody, WC1 Antibody, WND Antibody

More alternative names for the antibody
ATP7B antibody|ATP7B_HUMAN antibody|ATPase, Cu(2+) transporting, beta polypeptide antibody|ATPase, Cu++ transporting, beta polypeptide antibody|Copper pump 2 antibody|Copper transporting ATPase 2 antibody|PWD antibody|Toxic milk antibody|tx antibody|WC1 antibody|WD antibody|Wilson disease associated protein antibody|Wilson disease-associated protein antibody|WND antibody|WND/140 kDa antibody
Anti-ATP7b antibody [EPR6794] (ab124973)
Close sc-373964|sc-33826|sc-32446|sc-32445|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ATP7B Antibody

Catalogue No.

CSB-PA002415ESR2HU

Reactivity

Human

Immunogen

Recombinant human Copper-transporting ATPase 2 protein (1166-1465AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

157 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:540( Human), Omim:606882( Human), SwissProt:P35670( Human), Unigene:492280( Human)

Protein function

Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. .

Protein tissue specificity

Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.

Involvement in disease

Wilson disease (WD) [MIM:277900]: An autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule.

Protein post-translational modifications

Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.

Protein cellular localization

Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Late endosome . Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). Not redistributed to the plasma membrane in response to elevated copper levels. .; Isoform 1: Golgi apparatus membrane ; Multi-pass membrane protein .; Isoform 2: Cytoplasm .; WND/140 kDa: Mitochondrion .

Research area

All research areas>Transport and Trafficking>ATP7
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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