Anti-ATPIF1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ATPIF1 Antibody (CSB-PA883434ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Inhibitor of F(1)F(o)-ATPase Antibody,ATPIF1 Antibody,ATPI Antibody

More alternative names for the antibody
ATIF1_HUMAN antibody|ATP synthase inhibitor protein antibody|ATPase inhibitor antibody|ATPase inhibitor mitochondrial antibody|ATPase inhibitor protein antibody|ATPase inhibitory factor 1 antibody|ATPI antibody|ATPIF 1 antibody|Atpif1 antibody|ATPIP antibody|IF(1) antibody|IF1 antibody|Inhibitor of F(1)F(o)-ATPase antibody|IP antibody|MGC1167 antibody|MGC8898 antibody|mitochondrial antibody
Anti-ATPase Inhibitory Factor 1 antibody [5E2D7] (ab110277)
Close sc-271614|sc-134962|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ATPIF1 Antibody

Catalogue No.

CSB-PA883434ESR1HU

Reactivity

Human

Immunogen

Recombinant human ATPase inhibitor, mitochondrial protein (26-106AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

12 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:327699( Cow), Entrez Gene:93974( Human), Entrez Gene:11983( Mouse), Entrez Gene:25392( Rat), SwissProt:P01096( Cow), SwissProt:Q9UII2( Human), SwissProt:O35143( Mouse), SwissProt:Q03344( Rat), Unigene:726089( Human), Unigene:2171( Mouse), Unigene:1658( Rat)

Protein function

Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. .

Protein sequence and domain

Belongs to the ATPase inhibitor family. Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5A1-ATP5B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5C1). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By similarity).

Protein post-translational modifications

Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid.

Protein cellular localization

Mitochondrion .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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