Anti-BAP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-BAP1 Antibody (CSB-PA849763ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

BRCA1-associated protein 1 Antibody,Cerebral protein 6 Antibody,BAP1 Antibody,KIAA0272 Antibody,hucep-6 Antibody

More alternative names for the antibody
BAP 1 antibody|Bap1 antibody|BAP1_HUMAN antibody|BRCA 1 associated protein 1 antibody|BRCA1 associated protein 1 antibody|BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antibody|BRCA1-associated protein 1 antibody|Cerebral protein 13 antibody|Cerebral protein 6 antibody|DKFZp686N04275 antibody|FLJ35406 antibody|FLJ37180 antibody|HUCEP 13 antibody|Hucep 6 antibody|HUCEP13 antibody|Hucep6 antibody|KIAA0272 antibody|TPDS antibody|Ubiquitin carboxy terminal hydrolase antibody|Ubiquitin carboxyl terminal hydrolase BAP 1 antibody|Ubiquitin carboxyl terminal hydrolase BAP1 antibody|Ubiquitin carboxyl-terminal hydrolase BAP1 antibody|UCHL2 antibody
Anti-RING2 / RING1B / RNF2 antibody – ChIP Grade (ab3832)
Close sc-101109|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:200-1000

Recommended protocols: check protocols

Name

Anti-BAP1 Antibody

Catalogue No.

CSB-PA849763ESR2HU

Reactivity

Human

Immunogen

Recombinant human Protein BANP protein (460-729AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:200-1000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

80 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6045( Human), Entrez Gene:19821( Mouse), Omim:608985( Human), SwissProt:Q99496( Human), SwissProt:Q9CQJ4( Mouse), Unigene:591490( Human), Unigene:482250( Mouse)

Protein function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at ‘Lys-119’ (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward ‘Lys-48’-linked polyubiquitin chains compared to ‘Lys-63’-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor. .

Protein tissue specificity

Highly expressed in testis, placenta and ovary. Expressed in breast. .

Involvement in disease

Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. . Note=The gene represented in this entry is involved in disease pathogenesis.; Tumor predisposition syndrome (TPDS) [MIM:614327]: A condition characterized by predisposition to develop a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma, cutaneous melanoma, malignant mesothelioma on exposure to asbestos, lung adenocarcinoma and meningioma. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase C12 family. BAP1 subfamily.

Protein post-translational modifications

Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). .

Research area

All research areas>Tumor Suppressor/Apoptosis>BAP1
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!