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Rabbit Anti-BCL10 Antibody (CSB-PA002608ESR2HU)
Supplier: CUSABIO BIOTECH CO.
B-cell CLL/lymphoma 10 Antibody,Bcl-10 Antibody,CARD-containing molecule enhancing NF-kappa-B Antibody,CARD-like apoptotic protein Antibody,hCLAP Antibody,CED-3/ICH-1 prodomain homologous E10-like regulator Antibody,CIPER Antibody,Cellular homolog of vCARMEN Antibody,cCARMEN Antibody,Cellular-E10 Antibody,c-E10 Antibody,Mammalian CARD-containing adapter molecule E10 Antibody,mE10 Antibody,BCL10 Antibody,CIPER Antibody, CLAP AntibodyMore alternative names for the antibody
AI132454 antibody|B cell CLL/lymphoma 10 antibody|B cell lymphoma/leukemia10 antibody|B-cell CLL/lymphoma 10 antibody|B-cell leukemia/lymphoma 10 antibody|B-cell lymphoma/leukemia 10 antibody|Bcl 10 antibody|Bcl-10 antibody|Bcl10 antibody|BCL10_HUMAN antibody|c E10 antibody|c-E10 antibody|C81403 antibody|CARD containing apoptotic signaling protein antibody|CARD containing molecule enhancing NF kappa B antibody|CARD containing molecule enhancing NF kB antibody|CARD containing molecule enhancing NF-kB antibody|CARD containing molecule enhancing NFkB antibody|CARD containing proapoptotic protein antibody|CARD like apoptotic protein antibody|CARD-containing apoptotic signaling protein antibody|CARD-containing molecule enhancing NF-kappa-B antibody|CARD-containing proapoptotic protein antibody|CARD-like apoptotic protein antibody|CARMEN antibody|Caspase recruiting domain containing protein antibody|caspase-recruiting domain-containing protein antibody|cCARMEN antibody|cE 10 antibody|cE10 antibody|CED 3/ICH 1 prodomain homologous E10 like regulator antibody|CED-3/ICH-1 prodomain homologous E10-like regulator antibody|CED3/ICH1 prodomain homologous E10 like regulator antibody|Cellular E10 antibody|Cellular homolog of vCARMEN antibody|Cellular-E10 antibody|CIPER antibody|CLAP antibody|hCLAP antibody|Mammalian CARD containing adapter molecule E10 antibody|Mammalian CARD-containing adapter molecule E10 antibody|mE 10 antibody|mE10 antibody|R-RCD1 antibody
Anti-Bcl10 antibody [EP606Y] (ab33905)
Anti-Bcl10 antibody [EP606Y] (ab33905)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human B-cell lymphoma/leukemia 10 protein (1-233AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). .
|Protein tissue specificity|| |
|Involvement in disease|| |
Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.; Immunodeficiency 37 (IMD37) [MIM:616098]: A form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Lymphoma, mucosa-associated lymphoid type (MALTOMA) [MIM:137245]: A subtype of non-Hodgkin lymphoma, originating in mucosa-associated lymphoid tissue. MALT lymphomas occur most commonly in the gastro-intestinal tract but have been described in a variety of extranodal sites including the ocular adnexa, salivary gland, thyroid, lung, thymus, and breast. Histologically, they are characterized by an infiltrate of small to medium-sized lymphocytes with abundant cytoplasm and irregularly shaped nuclei. Scattered transformed blasts (large cells) also are present. Non-malignant reactive follicles are observed frequently. A pivotal feature is the presence of lymphoepithelial lesions, with invasion and partial destruction of mucosal glands and crypts by aggregates of tumor cells. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. .
|Protein cellular localization|| |
Cytoplasm, perinuclear region . Membrane raft . Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
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CUSABIO BIOTECH CO.
|Product type|| |
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