Anti-BCL11A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-BCL11A Antibody (CSB-PA872429ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

BCL-11A Antibody,B-cell CLL/lymphoma 11A Antibody,COUP-TF-interacting protein 1 Antibody,Ecotropic viral integration site 9 protein homolog Antibody,EVI-9 Antibody,Zinc finger protein 856 Antibody,BCL11A Antibody,CTIP1 Antibody, EVI9 Antibody, KIAA1809 Antibody, ZNF856 Antibody

More alternative names for the antibody
B cell CLL lymphoma 11A antibody|B cell CLL lymphoma 11B antibody|B cell CLL/lymphoma 11A antibody|B cell CLL/lymphoma 11B antibody|B cell lymphoma leukemia 11A antibody|BCL 11 A antibody|BCL 11 B antibody|BCL11A antibody|BCL11B antibody|C2H2 type zinc finger protein antibody|COUP TF interacting protein 1 antibody|COUP TF interacting protein 2 antibody|Ctip 1 antibody|Ctip 2 antibody|Ecotropic viral integration site 9 protein homolog antibody|EV I9 antibody|EV19 antibody|EVI9 antibody|FLJ10173 antibody|FLJ34997 antibody|hRIT 1 alpha antibody|hRIT1 alpha antibody|KIAA1809 antibody|Radiation induced tumor suppressor gene 1 protein antibody|RIT 1 antibody|RIT1 antibody|Zinc finger protein hRit1 alpha antibody|ZNF856 antibody
Anti-Ctip1 + Ctip2 antibody (ab82702)
Close sc-33095|sc-365320|sc-365988|sc-98513|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-BCL11A Antibody

Catalogue No.

CSB-PA872429ESR1HU

Reactivity

Human

Immunogen

Recombinant human B-cell lymphoma/leukemia 11A protein (1-230AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

91 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:53335( Human), Entrez Gene:64919( Human), Entrez Gene:14025( Mouse), Entrez Gene:58208( Mouse), Omim:606557( Human), Omim:606558( Human), SwissProt:Q9C0K0( Human), SwissProt:Q9H165( Human), SwissProt:Q99PV8( Mouse), SwissProt:Q9QYE3( Mouse)

Protein function

Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). .

Protein tissue specificity

Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. .

Involvement in disease

Note=Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. .; Intellectual developmental disorder with persistence of fetal hemoglobin (IDPFH) [MIM:617101]: An autosomal dominant disorder characterized by delayed psychomotor development, intellectual disability, variable dysmorphic features, including microcephaly, downslanting palpebral fissures, strabismus, and external ear abnormalities, and asymptomatic persistence of fetal hemoglobin. . Note=The disease is caused by mutations affecting the gene represented in this entry. .

Protein sequence and domain

The N-terminus is involved in protein dimerization and in transactivation of transcription.

Protein post-translational modifications

Sumoylated with SUMO1. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). .; Isoform 2: Cytoplasm . Nucleus . Note=Predominantly localized in the nucleus in nuclear paraspeckles. .; Isoform 3: Cytoplasm . Nucleus . Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles. .

Research area

All research areas>Tumor Suppressor/Apoptosis>Bcl-11
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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