Anti-BIRC2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-BIRC2 Antibody (CSB-PA618777ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

C-IAP1 Antibody,IAP homolog B Antibody,Inhibitor of apoptosis protein 2 Antibody,IAP-2 Antibody,hIAP-2 Antibody,hIAP2 Antibody,RING finger protein 48 Antibody,TNFR2-TRAF-signaling complex protein 2 Antibody,BIRC2 Antibody,API1 Antibody, IAP2 Antibody, MIHB Antibody, RNF48 Antibody

More alternative names for the antibody
API 1 antibody|API1 antibody|Apoptosis inhibitor 1 antibody|Baculoviral IAP repeat containing 2 antibody|Baculoviral IAP repeat containing protein 2 antibody|Baculoviral IAP repeat-containing protein 2 antibody|BIRC 2 antibody|BIRC2 antibody|BIRC2_HUMAN antibody|C IAP1 antibody|C-IAP1 antibody|cIAP 1 antibody|cIAP1 antibody|HIAP 2 antibody|HIAP-2 antibody|HIAP2 antibody|IAP 2 antibody|IAP homolog B antibody|IAP-2 antibody|IAP2 antibody|Inhibitor of apoptosis protein 2 antibody|MIHB antibody|NFR2 TRAF signalling complex protein antibody|RING finger protein 48 antibody|RNF 48 antibody|RNF48 antibody|TNFR2 TRAF signaling complex protein 2 antibody|TNFR2-TRAF-signaling complex protein 2 antibody
Anti-cIAP1 antibody (ab2399)
Close sc-271419|sc-7943|sc-1867|sc-12410|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-BIRC2 Antibody

Catalogue No.

CSB-PA618777ESR1HU

Reactivity

Human

Immunogen

Recombinant human Baculoviral IAP repeat-containing protein 2 protein (1-300AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

69 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:329( Human), Entrez Gene:11797( Mouse), Entrez Gene:60371( Rat), Omim:601712( Human), SwissProt:Q13490( Human), SwissProt:Q62210( Mouse), Unigene:696238( Human), Unigene:335659( Mouse), Unigene:205955( Rat)

Protein function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. .

Protein tissue specificity

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Protein sequence and domain

Belongs to the IAP family. The BIR domains mediate nuclear localization.; The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation.

Protein post-translational modifications

Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Protein cellular localization

Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Research area

All research areas>Tumor Suppressor/Apoptosis>IAP
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!