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Rabbit Anti-BIRC7 Antibody (CSB-PA839300ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Kidney inhibitor of apoptosis protein Antibody,KIAP Antibody,Livin Antibody,Melanoma inhibitor of apoptosis protein Antibody,ML-IAP Antibody,RING finger protein 50 Antibody,Truncated livin Antibody,p30-Livin Antibody,tLivin Antibody,BIRC7 Antibody,KIAP Antibody,LIVIN Antibody,MLIAP Antibody,RNF50 AntibodyMore alternative names for the antibody
Baculoviral IAP repeat containing 7 antibody|Baculoviral IAP repeat containing protein 7 antibody|Baculoviral IAP repeat-containing protein 7 antibody|BIRC 7 antibody|birc7 antibody|BIRC7_HUMAN antibody|KIAP antibody|Kidney inhibitor of apoptosis protein antibody|Livin antibody|Livin inhibitor of apotosis antibody|Melanoma inhibitor of apoptosis protein antibody|ML IAP antibody|ML-IAP antibody|MLIAP antibody|RING finger protein 50 antibody|RNF 50 antibody|RNF50 antibody
Anti-Livin antibody (ab97350)
Anti-Livin antibody (ab97350)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:200-1000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Baculoviral IAP repeat-containing protein 7 protein (1-265AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. .
|Protein tissue specificity|| |
Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
|Protein sequence and domain|| |
Belongs to the IAP family. The RING domain is essential for autoubiquitination.
|Protein post-translational modifications|| |
Autoubiquitinated and undergoes proteasome-mediated degradation.; The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Golgi apparatus . Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
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CUSABIO BIOTECH CO.
|Product type|| |
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