Anti-BRCC3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-BRCC3 Antibody (CSB-PA002798ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

BRCA1-A complex subunit BRCC36 Antibody,BRCA1/BRCA2-containing complex subunit 3 Antibody,BRCA1/BRCA2-containing complex subunit 36 Antibody,BRISC complex subunit BRCC36 Antibody,BRCC3 Antibody,BRCC36 Antibody, C6.1A Antibody, CXorf53 Antibody

More alternative names for the antibody
BRCA1-A complex subunit BRCC36 antibody|BRCA1/BRCA2 containing complex subunit 3 antibody|BRCA1/BRCA2 containing complex subunit 36 antibody|BRCA1/BRCA2-containing complex subunit 3 antibody|BRCA1/BRCA2-containing complex subunit 36 antibody|Brcc3 antibody|BRCC3_HUMAN antibody|BRCC36 antibody|BRISC complex subunit BRCC36 antibody|C6.1A antibody|Chromosome X open reading frame 53 antibody|CXorf53 antibody|Lys-63-specific deubiquitinase BRCC36 antibody|OTTHUMP00000061450 antibody
Anti-BRCC36 antibody (ab62075)
Close sc-131122|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-BRCC3 Antibody

Catalogue No.

CSB-PA002798ESR2HU

Reactivity

Human

Immunogen

Recombinant human Lys-63-specific deubiquitinase BRCC36 protein (1-316AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

36 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:79184( Human), Entrez Gene:210766( Mouse), Entrez Gene:316794( Rat), Omim:300617( Human), SwissProt:P46736( Human), SwissProt:P46737( Mouse), SwissProt:B2RYM5( Rat), Unigene:558537( Human), Unigene:226957( Mouse), Unigene:52727( Rat)

Protein function

Metalloprotease that specifically cleaves ‘Lys-63’-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward ‘Lys-48’-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes ‘Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes ‘Lys-63’-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves ‘Lys-63’-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific ‘Lys-63’-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). .

Protein tissue specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. .

Involvement in disease

Note=A chromosomal aberration involving BRCC3 is a cause of pro-lymphocytic T-cell leukemia (T-PLL). Translocation t(X;14)(q28;q11) with TCRA. .

Protein sequence and domain

Belongs to the peptidase M67A family. BRCC36 subfamily.

Protein cellular localization

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with FAM175B/ABRO1 retains BRCC3 in the cytoplasm (PubMed:20656690). .

Research area

All research areas>Tumor Suppressor/Apoptosis>BRCC
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!