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Rabbit Anti-BRCC3 Antibody (CSB-PA002798ESR2HU)
Supplier: CUSABIO BIOTECH CO.
BRCA1-A complex subunit BRCC36 Antibody,BRCA1/BRCA2-containing complex subunit 3 Antibody,BRCA1/BRCA2-containing complex subunit 36 Antibody,BRISC complex subunit BRCC36 Antibody,BRCC3 Antibody,BRCC36 Antibody, C6.1A Antibody, CXorf53 AntibodyMore alternative names for the antibody
BRCA1-A complex subunit BRCC36 antibody|BRCA1/BRCA2 containing complex subunit 3 antibody|BRCA1/BRCA2 containing complex subunit 36 antibody|BRCA1/BRCA2-containing complex subunit 3 antibody|BRCA1/BRCA2-containing complex subunit 36 antibody|Brcc3 antibody|BRCC3_HUMAN antibody|BRCC36 antibody|BRISC complex subunit BRCC36 antibody|C6.1A antibody|Chromosome X open reading frame 53 antibody|CXorf53 antibody|Lys-63-specific deubiquitinase BRCC36 antibody|OTTHUMP00000061450 antibody
Anti-BRCC36 antibody (ab62075)
Anti-BRCC36 antibody (ab62075)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Lys-63-specific deubiquitinase BRCC36 protein (1-316AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:79184( Human), Entrez Gene:210766( Mouse), Entrez Gene:316794( Rat), Omim:300617( Human), SwissProt:P46736( Human), SwissProt:P46737( Mouse), SwissProt:B2RYM5( Rat), Unigene:558537( Human), Unigene:226957( Mouse), Unigene:52727( Rat)
|Protein function|| |
Metalloprotease that specifically cleaves ‘Lys-63’-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward ‘Lys-48’-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes ‘Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes ‘Lys-63’-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves ‘Lys-63’-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific ‘Lys-63’-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). .
|Protein tissue specificity|| |
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. .
|Involvement in disease|| |
Note=A chromosomal aberration involving BRCC3 is a cause of pro-lymphocytic T-cell leukemia (T-PLL). Translocation t(X;14)(q28;q11) with TCRA. .
|Protein sequence and domain|| |
Belongs to the peptidase M67A family. BRCC36 subfamily.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with FAM175B/ABRO1 retains BRCC3 in the cytoplasm (PubMed:20656690). .
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CUSABIO BIOTECH CO.
|Product type|| |
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