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Rabbit Anti-C8orf4 Antibody (CSB-PA882079ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Protein C8orf4 Antibody,Thyroid cancer protein 1 Antibody,TC-1 Antibody,C8orf4 AntibodyMore alternative names for the antibody
C8orf4 antibody|CH004_HUMAN antibody|Chromosome 8 open reading frame 4 antibody|Human thyroid cancer 1 antibody|MGC22806 antibody|TC-1 antibody|TC1 antibody|Thyroid cancer protein 1 antibody|Uncharacterized protein C8orf4 antibody
Anti-C8orf4 antibody (ab133885)
Anti-C8orf4 antibody (ab133885)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein C8orf4 protein (1-106AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). .
|Protein tissue specificity|| |
Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347). .
|Protein cellular localization|| |
Cytoplasm . Nucleus, nucleolus . Nucleus speckle . Nucleus . Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). .
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CUSABIO BIOTECH CO.
|Product type|| |
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