Anti-C8orf4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-C8orf4 Antibody (CSB-PA882079ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein C8orf4 Antibody,Thyroid cancer protein 1 Antibody,TC-1 Antibody,C8orf4 Antibody

More alternative names for the antibody
C8orf4 antibody|CH004_HUMAN antibody|Chromosome 8 open reading frame 4 antibody|Human thyroid cancer 1 antibody|MGC22806 antibody|TC-1 antibody|TC1 antibody|Thyroid cancer protein 1 antibody|Uncharacterized protein C8orf4 antibody
Anti-C8orf4 antibody (ab133885)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-C8orf4 Antibody

Catalogue No.

CSB-PA882079ESR1HU

Reactivity

Human

Immunogen

Recombinant human Protein C8orf4 protein (1-106AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

12 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:56892( Human), Entrez Gene:69068( Mouse), Omim:607702( Human), SwissProt:Q9NR00( Human), SwissProt:Q9D915( Mouse), Unigene:591849( Human)

Protein function

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). .

Protein tissue specificity

Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347). .

Protein cellular localization

Cytoplasm . Nucleus, nucleolus . Nucleus speckle . Nucleus . Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). .

Research area

All research areas>Tumor Suppressor/Apoptosis>TC
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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