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Rabbit Anti-CACNA1H Antibody (CSB-PA004404ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Voltage-dependent T-type calcium channel subunit alpha-1H Antibody,Low-voltage-activated calcium channel alpha1 3.2 subunit Antibody,Voltage-gated calcium channel subunit alpha Cav3.2 Antibody,CACNA1H AntibodyMore alternative names for the antibody
Alpha1 3.2 antibody|Alpha13.2 antibody|CAC1H_HUMAN antibody|CACNA 1H antibody|CACNA1 H antibody|CACNA1 HB antibody|Cacna1h antibody|CACNA1HB antibody|Calcium channel alpha13.2 subunit antibody|Calcium channel voltage dependent T type alpha 1H subunit antibody|Calcium channel, voltage-dependent, T type, alpha 1Hb subunit antibody|Cav 3.2 antibody|Cav T.2 antibody|Cav3.2 antibody|CavT.2 antibody|EIG 6 antibody|EIG6 antibody|Low voltage activated calcium channel alpha 13.2 subunit antibody|Low voltage activated calcium channel alpha1 3.2 subunit antibody|Low-voltage-activated calcium channel alpha1 3.2 subunit antibody|MNCb 1209 antibody|T type Cav3.2 antibody|Voltage dependent t type calcium channel alpha 1H subunit antibody|Voltage gated calcium channel alpha subunit Cav 3.2 antibody|Voltage gated calcium channel alpha subunit Cav T.2 antibody|Voltage gated calcium channel alpha subunit Cav3.2 antibody|Voltage gated calcium channel alpha subunit CavT.2 antibody|Voltage-dependent T-type calcium channel subunit alpha-1H antibody|Voltage-gated calcium channel subunit alpha Cav3.2 antibody
Anti-CACNA1H antibody [S55-10] (ab84815)
Anti-CACNA1H antibody [S55-10] (ab84815)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Voltage-dependent T-type calcium channel subunit alpha-1H protein (260-360AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). .
|Protein tissue specificity|| |
In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. Isoform 1 and isoform 2 are expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens. Isoform 2 is not detected in brain (PubMed:11751928). Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216). .
|Involvement in disease|| |
Epilepsy, idiopathic generalized 6 (EIG6) [MIM:611942]: A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Epilepsy, childhood absence 6 (ECA6) [MIM:611942]: A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Hyperaldosteronism, familial, 4 (HALD4) [MIM:617027]: A form of familial hyperaldosteronism, a disorder characterized by hypertension, elevated aldosterone levels despite low plasma renin activity, and abnormal adrenal steroid production. There is significant phenotypic heterogeneity, and some individuals never develop hypertension. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily. Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
|Protein post-translational modifications|| |
In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
|Protein cellular localization|| |
Membrane; Multi-pass membrane protein.
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|Product type|| |
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