Anti-CACNA2D2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CACNA2D2 Antibody (CSB-PA889145ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Voltage-dependent calcium channel subunit alpha-2/delta-2 Antibody,Voltage-gated calcium channel subunit alpha-2/delta-2 Antibody,CACNA2D2 Antibody,KIAA0558 Antibody

More alternative names for the antibody
Alpha 2 delta calcium channel subunit antibody|CA2D2_HUMAN antibody|CACNA2D antibody|Cacna2d2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody|Gene 26 antibody|KIAA0558 antibody|LUAC11.1 antibody|Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody|Voltage-dependent calcium channel subunit delta-2 antibody|Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
Anti-CACNA2D2 antibody [EPR12343] (ab173293)
Close sc-136423|sc-34768|sc-365911|sc-66822|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CACNA2D2 Antibody

Catalogue No.

CSB-PA889145ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Voltage-dependent calcium channel subunit alpha-2/delta-2 protein (20-200AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

129 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9254( Human), Entrez Gene:56808( Mouse), Entrez Gene:300992( Rat), Omim:607082( Human), SwissProt:Q9NY47( Human), SwissProt:Q6PHS9( Mouse), SwissProt:Q8CFG6( Rat), Unigene:476273( Human), Unigene:674666( Human), Unigene:273084( Mouse), Unigene:91563( Rat)

Protein function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. .

Protein tissue specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. .

Protein sequence and domain

Belongs to the calcium channel subunit alpha-2/delta family. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.

Protein post-translational modifications

May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). .

Protein cellular localization

Membrane ; Single-pass type I membrane protein . Note=Colocalizes with CACNA1A in lipid raft fractions. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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