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Rabbit Anti-CADM1 Antibody (CSB-PA004425ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Immunoglobulin superfamily member 4 Antibody,IgSF4 Antibody,Nectin-like protein 2 Antibody,NECL-2 Antibody,Spermatogenic immunoglobulin superfamily Antibody,SgIgSF Antibody,Synaptic cell adhesion molecule Antibody,SynCAM Antibody,Tumor suppressor in lung cancer 1 Antibody,TSLC-1 Antibody,CADM1 AntibodyMore alternative names for the antibody
BL2 antibody|Cadm1 antibody|CADM1_HUMAN antibody|Cell adhesion molecule 1 antibody|IgSF4 antibody|IGSF4A antibody|Immunoglobulin superfamily member 4 antibody|immunoglobulin superfamily, member 4 antibody|immunosuperfamily protein Bl2 mRNA antibody|ISGF4 antibody|NECL-2 antibody|NECL2 antibody|Nectin-like protein 2 antibody|RA175 antibody|SgIGSF antibody|Spermatogenic immunoglobulin superfamily antibody|ST17 antibody|sTSLC-1 antibody|Synaptic cell adhesion molecule antibody|SynCAM antibody|SYNCAM1 antibody|TSLC-1 antibody|Tumor suppressor in lung cancer 1 antibody
Anti-SynCAM antibody (ab3910)
Anti-SynCAM antibody (ab3910)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cell adhesion molecule 1 protein (45-344AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:23705( Human), Entrez Gene:54725( Mouse), Entrez Gene:363058( Rat), Omim:605686( Human), SwissProt:Q9BY67( Human), SwissProt:Q8R5M8( Mouse), Unigene:370510( Human), Unigene:234832( Mouse), Unigene:19928( Rat)
|Protein function|| |
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. .
|Protein sequence and domain|| |
Belongs to the nectin family. The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
|Protein post-translational modifications|| |
Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction. .
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. .
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CUSABIO BIOTECH CO.
|Product type|| |
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