Anti-CADM1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CADM1 Antibody (CSB-PA004425ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Immunoglobulin superfamily member 4 Antibody,IgSF4 Antibody,Nectin-like protein 2 Antibody,NECL-2 Antibody,Spermatogenic immunoglobulin superfamily Antibody,SgIgSF Antibody,Synaptic cell adhesion molecule Antibody,SynCAM Antibody,Tumor suppressor in lung cancer 1 Antibody,TSLC-1 Antibody,CADM1 Antibody

More alternative names for the antibody
BL2 antibody|Cadm1 antibody|CADM1_HUMAN antibody|Cell adhesion molecule 1 antibody|IgSF4 antibody|IGSF4A antibody|Immunoglobulin superfamily member 4 antibody|immunoglobulin superfamily, member 4 antibody|immunosuperfamily protein Bl2 mRNA antibody|ISGF4 antibody|NECL-2 antibody|NECL2 antibody|Nectin-like protein 2 antibody|RA175 antibody|SgIGSF antibody|Spermatogenic immunoglobulin superfamily antibody|ST17 antibody|sTSLC-1 antibody|Synaptic cell adhesion molecule antibody|SynCAM antibody|SYNCAM1 antibody|TSLC-1 antibody|Tumor suppressor in lung cancer 1 antibody
Anti-SynCAM antibody (ab3910)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CADM1 Antibody

Catalogue No.

CSB-PA004425ESR2HU

Reactivity

Human

Immunogen

Recombinant human Cell adhesion molecule 1 protein (45-344AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

48 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23705( Human), Entrez Gene:54725( Mouse), Entrez Gene:363058( Rat), Omim:605686( Human), SwissProt:Q9BY67( Human), SwissProt:Q8R5M8( Mouse), Unigene:370510( Human), Unigene:234832( Mouse), Unigene:19928( Rat)

Protein function

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. .

Protein sequence and domain

Belongs to the nectin family. The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.

Protein post-translational modifications

Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction. .

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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