Anti-CALCOCO1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CALCOCO1 Antibody (CSB-PA878956ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Calcium-binding and coiled-coil domain-containing protein 1 Antibody,Calphoglin Antibody,Coiled-coil coactivator protein Antibody,Sarcoma antigen NY-SAR-3 Antibody,CALCOCO1 Antibody,KIAA1536 Antibody,PP13275 Antibody,UNQ2436/PRO4996 Antibody

More alternative names for the antibody
Calcium binding and coiled coil domain 1 antibody|CALCOCO1 antibody|Calphoglin antibody|Coiled coil coactivator protein antibody|Coiled coil leucine zipper coactivator 1 antibody|Coiled coil transcriptional coactivator antibody|Inorganic pyrophosphatase activator antibody|KIAA1536 antibody|PP13275 antibody|Sarcoma antigen NY-SAR-3 antibody
Anti-CoCoA antibody (ab70564)
Close sc-161424|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CALCOCO1 Antibody

Catalogue No.

CSB-PA878956ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Calcium-binding and coiled-coil domain-containing protein 1 protein (462-691AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

77 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:57658( Human), Entrez Gene:67488( Mouse), Entrez Gene:246047( Rat), SwissProt:Q9P1Z2( Human), SwissProt:Q8CGU1( Mouse), SwissProt:Q66HR5( Rat), Unigene:156667( Human)

Protein function

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). .; Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. .

Protein sequence and domain

Belongs to the CALCOCO family. The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).; The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).; Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.

Protein cellular localization

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. .

Research area

All research areas>Kinases and Phosphatases>CALCOCO
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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