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Rabbit Anti-CALCOCO2 Antibody (CSB-PA614394ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Calcium-binding and coiled-coil domain-containing protein 2 Antibody,Antigen nuclear dot 52 kDa protein Antibody,Nuclear domain 10 protein NDP52 Antibody,Nuclear domain 10 protein 52 Antibody,CALCOCO2 Antibody,NDP52 AntibodyMore alternative names for the antibody
Antigen nuclear dot 52 kDa protein antibody|CACO2_HUMAN antibody|Calcium binding and coiled coil domain 2 antibody|Calcium binding and coiled coil domain containing protein 2 antibody|Calcium-binding and coiled-coil domain-containing protein 2 antibody|CALCOCO 2 antibody|CALCOCO2 antibody|MGC17318 antibody|NDP52 antibody|Nuclear domain 10 protein 52 antibody|Nuclear domain 10 protein antibody|Nuclear domain 10 protein NDP52 antibody|Nuclear domain protein 52 antibody|Nuclear dot protein 52 antibody|OTTHUMP00000218344 antibody|OTTHUMP00000218345 antibody|OTTHUMP00000218346 antibody|OTTHUMP00000218347 antibody|OTTHUMP00000218349 antibody|OTTHUMP00000218351 antibody
Anti-CALCOCO2 antibody (ab68588)
Anti-CALCOCO2 antibody (ab68588)
Recommended applications: ELISA, WB, IHC, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)
ELISA, WB, IHC, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). .
|Protein tissue specificity|| |
Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. .
|Protein sequence and domain|| |
Belongs to the CALCOCO family. The MYO6-binding domain is required for autophagy-mediated degradation of infecting bacteria such as Salmonella typhimurium, but not for bacteria targeting to autophagosomes.; The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation.; The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation.; The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria.
|Protein cellular localization|| |
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein . Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. .
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|Product type|| |
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