Anti-CALD1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CALD1 Antibody (CSB-PA004441DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CDM Antibody,CALD1 Antibody,CAD Antibody, CDM Antibody

More alternative names for the antibody
CAD antibody|CALD 1 antibody|CALD1 antibody|CALD1_HUMAN antibody|Caldesmon 1 antibody|Caldesmon 1 Isoform 1 antibody|Caldesmon 1 Isoform 2 antibody|Caldesmon 1 Isoform 3 antibody|Caldesmon 1 Isoform 4 antibody|Caldesmon 1 Isoform 5 antibody|Caldesmon antibody|Caldesmon1 antibody|CDM antibody|H CAD antibody|HCAD antibody|L CAD antibody|LCAD antibody|MGC21352 antibody|NAG22 antibody
Anti-Caldesmon antibody [E89] (ab32330)
Close sc-135965|sc-271222|sc-7574|sc-58700|sc-15374|sc-7575|sc-130401|sc-390250|sc-98427|sc-48352|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CALD1 Antibody

Catalogue No.

CSB-PA004441DSR1HU

Reactivity

Human

Immunogen

Recombinant human Caldesmon protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

93 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:800( Human), Entrez Gene:109624( Mouse), Entrez Gene:25687( Rat), Omim:114213( Human), SwissProt:Q05682( Human), SwissProt:Q62736( Rat), Unigene:490203( Human), Unigene:308134( Mouse), Unigene:204926( Rat)

Protein function

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). .

Protein tissue specificity

High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Protein sequence and domain

Belongs to the caldesmon family. The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.

Protein post-translational modifications

In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). .

Protein cellular localization

Cytoplasm, cytoskeleton . Cytoplasm, myofibril . Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). .

Research area

All research areas>Tumor Suppressor/Apoptosis>CAD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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