Anti-CALHM1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CALHM1 Antibody (CSB-PA808532ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein FAM26C Antibody,CALHM1 Antibody,FAM26C Antibody

More alternative names for the antibody
CAHM1_HUMAN antibody|Calcium homeostasis modulator 1 antibody|Calcium homeostasis modulator protein 1 antibody|CALHM1 antibody|FAM26C antibody|Family with sequence similarity 26, member C antibody|MGC39514 antibody|MGC39617 antibody|OTTHUMP00000020413 antibody|Protein FAM26C antibody
Anti-CALHM1 antibody (ab106561)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CALHM1 Antibody

Catalogue No.

CSB-PA808532ESR1HU

Reactivity

Human

Immunogen

Recombinant human Calcium homeostasis modulator protein 1 protein (202-346AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:255022( Human), Entrez Gene:546729( Mouse), Entrez Gene:499367( Rat), Omim:612234( Human), SwissProt:Q8IU99( Human), Unigene:680365( Human)

Protein function

Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. .

Protein tissue specificity

Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. .

Protein sequence and domain

Belongs to the FAM26 family.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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