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Rabbit Anti-CALHM1 Antibody (CSB-PA808532ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Protein FAM26C Antibody,CALHM1 Antibody,FAM26C AntibodyMore alternative names for the antibody
CAHM1_HUMAN antibody|Calcium homeostasis modulator 1 antibody|Calcium homeostasis modulator protein 1 antibody|CALHM1 antibody|FAM26C antibody|Family with sequence similarity 26, member C antibody|MGC39514 antibody|MGC39617 antibody|OTTHUMP00000020413 antibody|Protein FAM26C antibody
Anti-CALHM1 antibody (ab106561)
Anti-CALHM1 antibody (ab106561)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-5000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Calcium homeostasis modulator protein 1 protein (202-346AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=255022" target="_blank">Entrez Gene:255022( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=546729" target="_blank">Entrez Gene:546729( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=499367" target="_blank">Entrez Gene:499367( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/612234" target="_blank">Omim:612234( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q8IU99" target="_blank">SwissProt:Q8IU99( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=680365" target="_blank">Unigene:680365( Human)</a>
|Protein function|| |
Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. .
|Protein tissue specificity|| |
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. .
|Protein sequence and domain|| |
Belongs to the FAM26 family.
|Protein cellular localization|| |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum.
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CUSABIO BIOTECH CO.
|Product type|| |
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