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Rabbit Anti-CALR3 Antibody (CSB-PA856970ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Calreticulin-2 Antibody,Calsperin Antibody,CALR3 Antibody,CRT2 AntibodyMore alternative names for the antibody
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Calreticulin-3 protein (135-384AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. .
|Protein tissue specificity|| |
Testis specific. .
|Involvement in disease|| |
Cardiomyopathy, familial hypertrophic 19 (CMH19) [MIM:613875]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the calreticulin family. Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).; The interaction with glycans occurs through a binding site in the globular lectin domain.; The zinc binding sites are localized to the N-domain.
|Protein cellular localization|| |
Endoplasmic reticulum lumen .
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CUSABIO BIOTECH CO.
|Product type|| |
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