Anti-CAMK2B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CAMK2B Antibody (CSB-PA618786ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Calcium/calmodulin-dependent protein kinase type II subunit beta Antibody,CaM kinase II subunit beta Antibody,CaMK-II subunit beta Antibody,CAMK2B Antibody,CAM2 Antibody,CAMK2 Antibody,CAMKB Antibody

More alternative names for the antibody
CaM kinase II antibody|CaM kinase II beta chain antibody|CaM kinase II gamma chain antibody|CAM2 antibody|CAMK antibody|CAMK II antibody|CaMK II beta subunit antibody|CaMK II subunit gamma antibody|CAMK2 antibody|CAMKB antibody|CAMKG antibody|Proline rich calmodulin dependent protein kinase antibody
Anti-CamKII gamma antibody [8G10C1] (ab201966)
Close sc-517238|sc-1541|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CAMK2B Antibody

Catalogue No.

CSB-PA618786ESR2HU

Reactivity

Human

Immunogen

Recombinant human Calcium/calmodulin-dependent protein kinase type II subunit beta protein (1-300AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

72 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:818( Human), Entrez Gene:171140( Rat), Omim:602123( Human), SwissProt:Q13555( Human), SwissProt:P11730( Rat)

Protein function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. .

Protein tissue specificity

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

Protein post-translational modifications

Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. .

Protein cellular localization

Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Research area

All research areas>Kinases and Phosphatases>CaMK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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