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Rabbit Anti-CAMK2D Antibody (CSB-PA613410ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Calcium/calmodulin-dependent protein kinase type II subunit delta Antibody,CaM kinase II subunit delta Antibody,CaMK-II subunit delta Antibody,CAMK2D Antibody,CAMKD AntibodyMore alternative names for the antibody
Calcium/calmodulin-dependent protein antibody|CaM kinase II beta subunit antibody|CaM-kinase II beta chain antibody|CAM2 antibody|CAMK antibody|CAMK-II antibody|CaMK-II beta subunit antibody|CAMK2B antibody|CAMK2D antibody|CAMK2G antibody|CAMK2N2 antibody|CAMKB antibody|CAMKD antibody|CAMKG antibody|KCC2B antibody|kinase CaMK2-beta antibody
Anti-CaMK2 beta gamma delta antibody (ab79359)
Anti-CaMK2 beta gamma delta antibody (ab79359)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Calcium/calmodulin-dependent protein kinase type II subunit delta protein (1-260AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:816( Human), Entrez Gene:817( Human), Entrez Gene:818( Human), Entrez Gene:108058( Mouse), Entrez Gene:12323( Mouse), Entrez Gene:12325( Mouse), Entrez Gene:171140( Rat), Entrez Gene:24245( Rat), Entrez Gene:24246( Rat), Omim:114078( Human), Omim:607707( Human), Omim:608721( Human), SwissProt:Q13554( Human), SwissProt:Q13555( Human), SwissProt:Q13557( Human), SwissProt:P28652( Mouse), SwissProt:Q6PHZ2( Mouse), SwissProt:Q923T9( Mouse), SwissProt:P08413( Rat), SwissProt:P11730( Rat), SwissProt:P15791( Rat), Unigene:351887( Human), Unigene:9743( Rat)
|Protein function|| |
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on ‘Ser-2808’. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. .
|Protein tissue specificity|| |
Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
|Protein post-translational modifications|| |
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. .
|Protein cellular localization|| |
Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
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CUSABIO BIOTECH CO.
|Product type|| |
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