Anti-CAMK4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-CAMK4 Antibody (CSB-PA614976ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CaMK IV Antibody,CaM kinase-GR Antibody,CAMK4 Antibody,CAMK Antibody,CAMK-GR Antibody, CAMKIV Antibody

More alternative names for the antibody
Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody|Brain Ca(2+) calmodulin dependent protein kinase type IV antibody|Brain Ca++-calmodulin dependent protein kinase type IV antibody|Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody|Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody|Calcium/calmodulin dependent protein kinase IV antibody|Calcium/calmodulin dependent protein kinase type IV antibody|Calcium/calmodulin-dependent protein kinase type IV antibody|CAM kinase 4 antibody|CAM kinase GR antibody|CAM kinase IV antibody|CAM kinase-GR antibody|CaMK 4 antibody|CAMK GR antibody|CaMK IV antibody|Camk4 antibody|CaMKGR antibody|IV antibody|KCC4_HUMAN antibody|MGC36771 antibody
Anti-CAMKIV antibody (ab3557)
Close sc-136249|sc-166156|sc-166157|sc-1545|sc-17762|sc-9036|sc-55501|

Recommended applications: ELISA, WB, IP

Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IP:1:200-1:2000

Recommended protocols: check protocols

Name

Anti-CAMK4 Antibody

Catalogue No.

CSB-PA614976ESR2HU

Reactivity

Human

Immunogen

Recombinant human Calcium/calmodulin-dependent protein kinase type IV protein (304-473AA)

Host

Rabbit

Applications

ELISA, WB, IP

Recommended dilution

Recommended dilution:WB:1:1000-1:5000,IP:1:200-1:2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

51 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:814( Human), Entrez Gene:12326( Mouse), Entrez Gene:25050( Rat), Omim:114080( Human), SwissProt:Q16566( Human), SwissProt:P08414( Mouse), SwissProt:P13234( Rat), Unigene:591269( Human), Unigene:222329( Mouse), Unigene:11046( Rat)

Protein function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on ‘Ser-133’ in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. .

Protein tissue specificity

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.

Protein post-translational modifications

Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13. .; Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation. .

Protein cellular localization

Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .

Research area

All research areas>Kinases and Phosphatases>CaMK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!