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Rabbit Anti-CAMK4 Antibody (CSB-PA614976ESR2HU)
Supplier: CUSABIO BIOTECH CO.
CaMK IV Antibody,CaM kinase-GR Antibody,CAMK4 Antibody,CAMK Antibody,CAMK-GR Antibody, CAMKIV AntibodyMore alternative names for the antibody
Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody|Brain Ca(2+) calmodulin dependent protein kinase type IV antibody|Brain Ca++-calmodulin dependent protein kinase type IV antibody|Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody|Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody|Calcium/calmodulin dependent protein kinase IV antibody|Calcium/calmodulin dependent protein kinase type IV antibody|Calcium/calmodulin-dependent protein kinase type IV antibody|CAM kinase 4 antibody|CAM kinase GR antibody|CAM kinase IV antibody|CAM kinase-GR antibody|CaMK 4 antibody|CAMK GR antibody|CaMK IV antibody|Camk4 antibody|CaMKGR antibody|IV antibody|KCC4_HUMAN antibody|MGC36771 antibody
Anti-CAMKIV antibody (ab3557)
Anti-CAMKIV antibody (ab3557)
Recommended applications: ELISA, WB, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Calcium/calmodulin-dependent protein kinase type IV protein (304-473AA)
ELISA, WB, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:814( Human), Entrez Gene:12326( Mouse), Entrez Gene:25050( Rat), Omim:114080( Human), SwissProt:Q16566( Human), SwissProt:P08414( Mouse), SwissProt:P13234( Rat), Unigene:591269( Human), Unigene:222329( Mouse), Unigene:11046( Rat)
|Protein function|| |
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on ‘Ser-133’ in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. .
|Protein tissue specificity|| |
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
|Protein post-translational modifications|| |
Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13. .; Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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